Natalie J. Jooss

MRC Weatherall Institute of Molecular Medicine — United Kingdom

Medicine · Health Sciences

13h-index474citations29works11.62yr avg
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Research Topics

Platelet Disorders and Treatments(16), Cell Adhesion Molecules Research(8), Blood groups and transfusion(6), Antiplatelet Therapy and Cardiovascular Diseases(4), Hematopoietic Stem Cell Transplantation(3)

Publications29 total

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders
Cell stem cell·2026Open Access
3062 – PLATELETS SEQUESTER EXTRACELLULAR DNA, CAPTURING TUMOR-DERIVED AND FREE FETAL DNA
Experimental Hematology·2025
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
Science·2025· 18 citedOpen Access
comBO: A combined human bone and lympho-myeloid bone marrow organoid for pre-clinical modelling of haematopoietic disorders
2025· 3 cited
Tolerance of Whole Genome Duplication in Megakaryocytes, and Consequences for Their Genome Integrity
Blood·2024
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis
Science Translational Medicine·2024· 20 citedOpen Access
Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice
Blood Advances·2024· 13 citedOpen Access
Generating human bone marrow organoids for disease modeling and drug discovery
Nature Protocols·2024· 47 citedOpen Access
Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1
Cellular and Molecular Life Sciences·2024· 3 citedOpen Access
Platelets Sequester Extracellular DNA, Capturing Tumour-Derived and Free Fetal DNA
Blood·2023· 4 cited
A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis
2023· 5 citedOpen Access
Platelet glycoprotein VI cluster size is related to thrombus formation and phosphatidylserine exposure in collagen-adherent platelets under arterial shear
Journal of Thrombosis and Haemostasis·2023· 11 citedOpen Access
Pharmacological Inhibition of Glycoprotein VI- and Integrin α2β1-Induced Thrombus Formation Modulated by the Collagen Type
Thrombosis and Haemostasis·2023· 8 cited
Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization
Journal of Thrombosis and Haemostasis·2023· 6 citedOpen Access
Targeting GPVI
2023Open Access
Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear
International Journal of Molecular Sciences·2022· 6 citedOpen Access
Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation
Journal of Thrombosis and Haemostasis·2022· 32 citedOpen Access
CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear
Thrombosis and Haemostasis·2022· 19 citedOpen Access
MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice
Biomedicines·2022· 8 citedOpen Access
Platelets fine-tune effector responses of naïve CD4+ T cells via platelet factor 4-regulated transforming growth factor β signaling
Cellular and Molecular Life Sciences·2022· 20 citedOpen Access
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Frequent Co-authors

Johan W. M. Heemskerk(10), Steve P. Watson(9), Natalie S. Poulter(9), Yvonne Henskens(8), Abdullah O. Khan(8), Bethan Psaila(7), Adam J. Mead(7), Antonio Rodriguez-Romera(6), Lauren C. Murphy(6), Zoë C. Wong(5), Julie Rayes(5), Mark R. Thomas(5), Camélia Benlabiod(5), Christina Simoglou Karali(5), Delia I. Fernández(4), Aude-Anaïs Olijnik(4), Christopher W. Smith(4), Alexandre Slater(4), Rong Li(4), Jennifer O’Sullivan(4)