David Irwin

University of Colorado Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.3kcitations144works1.42yr avg
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Research Topics

High Altitude and Hypoxia(43), Hemoglobinopathies and Related Disorders(35), Pulmonary Hypertension Research and Treatments(25), Hemoglobin structure and function(24), Neuroscience of respiration and sleep(20)

Publications144 total

Hemoglobin Binders Reduce Inflammation and Tissue Injury from Hemolysis in Venovenous Extracorporeal Circulation
Blood Advances·2026Open Access
Ferroportin Inhibition Attenuates Pulmonary Hypertension in Hypoxic Sickle Cell Disease Mice
Blood Advances·2026Open Access
Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent <i>S</i> -Nitroso Transfer
2025Open Access
Exercise as a Vital Sign in Cardiopulmonary Disease: Insights from Wave Intensity Analysis
American Journal of Physiology-Heart and Circulatory Physiology·2025Open Access
Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis
Pulmonary Circulation·2025Open Access
Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease
Biomedicine & Pharmacotherapy·2025Open Access
Increased Exercise Tolerance in G6PD African Variant Mice Driven by Metabolic Adaptations and Erythrophagocytosis
Antioxidants·2025· 2 citedOpen Access
Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice
Biotechnology and Bioengineering·2025· 1 citedOpen Access
Development of alveoli-distributed lung geometries for humans and rats to predict localized particle deposition in the respiratory tract
Journal of Aerosol Science·2025
Metabolic and Proteomic Divergence is Present in Spleens and Livers from Berkeley Sickle Cell Anemia and β-Thalassemia Mice
Journal of Proteome Research·2025· 1 citedOpen Access
Targeting lung heme iron by aerosol hemopexin adminstration in sickle cell disease pulmonary hypertension
Free Radical Biology and Medicine·2025· 2 citedOpen Access
Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension
Blood Advances·2024· 2 citedOpen Access
Increased exercise tolerance in humanized G6PD-deficient mice
Blood Advances·2024· 5 citedOpen Access
Low Dose Clodronate Improves Exercise Tolerance, Right Ventricular Function, and Alters Resident Lung Macrophage Phenotypes
Blood·2024
Peripheral Blood Macrophages (PBMCs) from Adults with Sickle Cell Disease Have a Unique Phenotype
Blood·2024Open Access
Got Oxygen? the Impact of Band 3 on RBC Function during Exercise
Blood·2024· 1 cited
Circulating Peripheral Blood Mononuclear Cells from Adults with Sickle Cell Disease (SCD)- Associated Pulmonary Hypertension (PH) Patients Have Increased Iron Content and a Unique Multi-Omic Signature
Blood·2024
Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle
International Journal of Molecular Sciences·2024· 3 citedOpen Access
Classical dendritic cells contribute to hypoxia‐induced pulmonary hypertension
The FASEB Journal·2024· 9 citedOpen Access
Understanding exercise (in)tolerance in sickle cell disease: impacts of hemolysis and exercise training on skeletal muscle oxygen delivery
Journal of Applied Physiology·2024· 4 cited
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Frequent Co-authors

Kurt R. Stenmark(17), Paul W. Buehler(15), Julie W. Harral(11), Eva Nozik‐Grayck(11), Karyn L. Hamilton(9), Susan M. Majka(8), Zoe Loomis(8), Kathryn L. Hassell(8), Rachelle Nuss(8), David I. Pak(7), Scott K. Ferguson(7), Dwight J. Klemm(6), Vijaya Karoor(6), Christina Lisk(6), Martha C. Tissot van Patot(6), Thies Schroeder(6), Jin Hyen Baek(6), Dominik J. Schaer(5), Edward C. Dempsey(5), Katherine Redinius(5)