Denise C. Hegan

Yale University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.3kcitations31works1.02yr avg
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Research Topics

DNA Repair Mechanisms(16), PARP inhibition in cancer therapy(9), RNA Interference and Gene Delivery(6), CRISPR and Genetic Engineering(5), Genetic factors in colorectal cancer(5)

Publications31 total

Abstract A100: Systemic targeting of therapeutic RNA into pancreatic tumors via an RNA-binding and cell-penetrating antibody
Cancer Research·2025
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer
Science Translational Medicine·2025· 4 cited
Abstract 6392: Next-generation ADCs: precise delivery of exatecan to tumor nuclei by targeting the tumor microenvironment with an anti-DNA cell-penetrating antibody
Cancer Research·2025
Abstract PR-01: Systemic targeting of therapeutic RNA to pancreatic ductal adenocarcinoma via a novel, cell-penetrating, and nucleic acid-binding monoclonal antibody
Cancer Research·2024
BBIT20 inhibits homologous DNA repair with disruption of the BRCA1–BARD1 interaction in breast and ovarian cancer
British Journal of Pharmacology·2021· 25 citedOpen Access
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Translational Oncology·2020· 23 citedOpen Access
Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in<i>VHL</i>-deficient human renal cell carcinoma
Oncotarget·2017· 35 citedOpen Access
Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and Radiation
International Journal of Radiation Oncology*Biology*Physics·2017Open Access
A cell-penetrating antibody inhibits human RAD51 via direct binding
Nucleic Acids Research·2017· 26 citedOpen Access
Abstract LB-290: Oncometabolites induce a BRCAness state that can be exploited by PARP inhibitors
Cancer Research·2017
Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells
Carcinogenesis·2017· 60 citedOpen Access
Abstract B25: “TargetDBR”—A DNA repair drug and target discovery collaboration: Exploiting synthetic lethal, high content, and functional cellular reporter assays to accelerate DNA repair targeted drug discovery
Molecular Cancer Research·2017
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Science Translational Medicine·2017· 551 cited
Abstract LB-029: Negative transcriptional and epigenetic regulation of DNA repair pathways by the heavy metals nickel and arsenic
Cancer Research·2016· 2 cited
Mechanism of Action Studies of Lomaiviticin A and the Monomeric Lomaiviticin Aglycon. Selective and Potent Activity Toward DNA Double-Strand Break Repair-Deficient Cell Lines
Journal of the American Chemical Society·2015· 18 citedOpen Access
The cytotoxicity of (−)-lomaiviticin A arises from induction of double-strand breaks in DNA
Nature Chemistry·2014· 80 citedOpen Access
Hypoxia and DNA repair.
PubMed·2013· 21 citedOpen Access
Abstract 4319: Lupus antibody-based cancer therapy.
Cancer Research·2013
Lupus antibody-based cancer therapy [Conference Abstract]
Cancer Research·2013
Targeting Cancer with a Lupus Autoantibody
Science Translational Medicine·2012· 5 citedOpen Access
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Frequent Co-authors

Peter M. Glazer(30), Ranjit S. Bindra(9), Susan E. Scanlon(7), Parker L. Sulkowski(6), Yanfeng Liu(4), Ranjini K. Sundaram(4), Yulia V. Surovtseva(4), Elias Quijano(4), Zaira Ianniello(4), Christopher D. Corso(3), Nathaniel D. Robinson(3), Karin Purshouse(3), Hanwen Bai(3), Nathan R. Fons(3), G. Breuer(3), Yuanbin Song(3), Maureen Kachman(3), Stephanie Halene(3), Murat Günel(3), Yuhong Lü(3)