Gregory S. Keyes

National Institutes of Health Clinical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index574citations26works0.22yr avg
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Research Topics

Eicosanoids and Hypertension Pharmacology(8), Fatty Acid Research and Health(7), Alzheimer's disease research and treatments(6), Neuroscience and Neuropharmacology Research(3), Analytical Chemistry and Chromatography(3)

Publications26 total

Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses
2026Open Access
Publisher Correction: Senolytic effects of a modified Gingerenone A
npj Aging·2025Open Access
Senolytic effects of a modified Gingerenone A
npj Aging·2025· 1 citedOpen Access
HYPOTHESIS: Lipid-protecting disulfide bridges are the missing molecular link between ApoE4 and sporadic Alzheimer's disease in humans
Prostaglandins Leukotrienes and Essential Fatty Acids·2025Open Access
Lipid-protecting disulfide bridges are the missing molecular link between ApoE4 and sporadic Alzheimer’s disease in humans
2025Open Access
ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease
Acta Neuropathologica Communications·2023· 17 citedOpen Access
ApoER2-Dab1 disruption as the origin of pTau-related neurodegeneration in sporadic Alzheimer's disease
Research Square (Research Square)·2023· 2 citedOpen Access
ApoER2-Dab1 disruption as the origin of pTau-related neurodegeneration in sporadic Alzheimer’s disease
2023Open Access
Endogenous Derivatives of Linoleic Acid and their Stable Analogs Are Potential Pain Mediators
JID Innovations·2022· 10 citedOpen Access
Biochemical and behavioral effects of decreasing dietary linoleic acid and increasing eicosapentaenoic acid and docosahexaenoic acid in a rat chronic monoarthrits model
Prostaglandins Leukotrienes and Essential Fatty Acids·2022· 2 citedOpen Access
Development of a Chiral Supercritical Fluid Chromatography–Tandem Mass Spectrometry and Reversed-Phase Liquid Chromatography–Tandem Mass Spectrometry Platform for the Quantitative Metabolic Profiling of Octadecanoid Oxylipins
Analytical Chemistry·2022· 48 citedOpen Access
Development of a chiral SFC-MS/MS and reversed-phase LC-MS/MS platform for the quantitative metabolic profiling of octadecanoid oxylipins
2022Open Access
Stable analogs of 13‑hydroxy-9,10-trans-epoxy-(11E)-octadecenoate (13,9-HEL), an oxidized derivative of linoleic acid implicated in the epidermal skin barrier
Prostaglandins Leukotrienes and Essential Fatty Acids·2021· 6 citedOpen Access
Lipid peroxidation induced ApoE receptor-ligand disruption as a unifying hypothesis underlying sporadic Alzheimer’s disease in humans
2021
Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial
BMJ·2021· 94 citedOpen Access
Molecular Pathways Linking Oxylipins to Nociception in Rats
Journal of Pain·2020· 22 citedOpen Access
A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch
UNC Libraries·2020Open Access
Hydroxy-epoxide and keto-epoxide derivatives of linoleic acid activate trigeminal neurons
Neurobiology of Pain·2020· 11 citedOpen Access
Lipidomic profiling of targeted oxylipins with ultra-performance liquid chromatography-tandem mass spectrometry
Analytical and Bioanalytical Chemistry·2018· 73 cited
Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2018· 37 citedOpen Access
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Frequent Co-authors

Christopher E. Ramsden(22), Mark S. Horowitz(10), Daisy Zamora(9), Anthony F. Domenichiello(8), Andrew J. Mannes(7), Zhi‐Xin Yuan(6), Sharon F. Majchrzak‐Hong(5), John M. Davis(5), Michael J. Iadarola(5), Dragan Maric(5), Xiufeng Li(5), Matthew R. Sapio(4), Joshua J. Wheeler(4), Jahandar Jahanipour(4), Andrea Sedlock(4), Santosh K. Mishra(3), Jacklyn R. Gross(3), Alexander V. Sorokin(3), Danielle M. LaPaglia(3), Michael R. Vasko(3)