Linda Millen

The University of Texas Southwestern Medical Center — United States

Medicine · Health Sciences

14h-index3.4kcitations23works71.02yr avg
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Research Topics

Cystic Fibrosis Research Advances(9), Advanced biosensing and bioanalysis techniques(5), Neonatal Respiratory Health Research(3), Drug Transport and Resistance Mechanisms(3), Legume Nitrogen Fixing Symbiosis(3)

Publications23 total

In vitro modulator responsiveness of 655 CFTR variants found in people with cystic fibrosis
Journal of Cystic Fibrosis·2024· 71 citedOpen Access
327 Data analysis for large-scale theratyping study of 656 CFTR variants
Journal of Cystic Fibrosis·2023Open Access
<i>In Vitro</i> Modulator Responsiveness of 655 <i>CFTR</i> Variants Found in People With CF
2023· 12 citedOpen Access
Role of transmembrane spanning domain 1 in cystic fibrosis transmembrane conductance regulator folding
2021Open Access
Comparative transcriptome analysis of the human endocervix and ectocervix during the proliferative and secretory phases of the menstrual cycle
Scientific Reports·2019· 12 citedOpen Access
Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface
Molecular Pharmacology·2017· 93 citedOpen Access
The BiP Molecular Chaperone Plays Multiple Roles during the Biogenesis of TorsinA, an AAA+ ATPase Associated with the Neurological Disease Early-onset Torsion Dystonia
Journal of Biological Chemistry·2014· 25 citedOpen Access
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene
Nature Genetics·2013· 614 citedOpen Access
1.270 A UNIQUE REDOX-SENSING SENSOR-II MOTIF IN TORSINA PLAYS A CRITICAL ROLE IN NUCLEOTIDE AND PARTNER BINDING
Parkinsonism & Related Disorders·2011· 1 cited
Alteration of CFTR transmembrane span integration by disease-causing mutations
Molecular Biology of the Cell·2011· 38 cited
Mutations that Disrupt Formation of Functional CFTR
Biophysical Journal·2011Open Access
A Unique Redox-sensing Sensor II Motif in TorsinA Plays a Critical Role in Nucleotide and Partner Binding
Journal of Biological Chemistry·2010· 52 citedOpen Access
The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis
Journal of Biological Chemistry·2010· 180 citedOpen Access
Gating of CFTR by the STAS domain of SLC26 transporters
Nature Cell Biology·2004· 464 citedOpen Access
Conformational Remodeling of Proteasomal Substrates by PA700, the 19 S Regulatory Complex of the 26 S Proteasome
Journal of Biological Chemistry·2002· 71 citedOpen Access
ATP Binding to the Motor Domain from an ABC Transporter Drives Formation of a Nucleotide Sandwich Dimer
Molecular Cell·2002· 767 citedOpen Access
Cooperative, ATP-dependent Association of the Nucleotide Binding Cassettes during the Catalytic Cycle of ATP-binding Cassette Transporters
Journal of Biological Chemistry·2002· 330 citedOpen Access
ATP BINDING TO THE MOTOR DOMAIN FORM AN ABC TRANSPORTER DRIVES FORMATION OF A NUCLEOTIDE SANDWICH DIMER
Bioorganic & Medicinal Chemistry·2002· 1 cited
The Crystal Structure of the MJ0796 ATP-binding Cassette
Journal of Biological Chemistry·2001· 243 citedOpen Access
Crystal Structures of the MJ1267 ATP Binding Cassette Reveal an Induced-Fit Effect at the ATPase Active Site of an ABC Transporter
Structure·2001· 283 citedOpen Access
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Frequent Co-authors

Philip Thomas(17), J.F. Hunt(7), Nathan K. Karpowich(5), Oksana Martsinkevich(4), Juan L. Mendoza(4), Jonathan Moody(3), Garry R. Cutting(3), Hermann Bihler(3), Andrey Sivachenko(3), Isaac Musisi(3), Noah Simon(3), Karen S. Raraigh(3), Robert J. Bridges(3), P.J. Thomas(3), Jane Rosen(2), Peter L. Dai(2), Priyanka Bhatt(2), Amita Thakerar Patel(2), Justin Chin(2), Violaine Bailey(2)