Joseph Avruch

University of Maryland, Baltimore — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

103h-index46.3kcitations262works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(77), PI3K/AKT/mTOR signaling in cancer(51), Melanoma and MAPK Pathways(38), Hippo pathway signaling and YAP/TAZ(33), Pancreatic function and diabetes(29)

Publications262 total

Role of liver transplantation in acute liver failure due to exertional heat stroke
HPB·2023Open Access
Human T2D associated gene IMP2/IGF2BP2 promotes the commitment of mesenchymal stem cells into adipogenic lineage
2022· 1 citedOpen Access
Human T2D associated gene IMP2/IGF2BP2 promotes the commitment of mesenchymal stem cells into adipogenic lineage
2022Open Access
Human T2D-Associated Gene <i>IMP2/IGF2BP2</i> Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage
Diabetes·2022· 10 citedOpen Access
Human T2D associated gene IMP2/IGF2BP2 promotes the commitment of mesenchymal stem cells into adipogenic lineage
2022Open Access
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression
Molecular Metabolism·2021· 51 citedOpen Access
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
Cell·2020· 74 citedOpen Access
Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation
Journal of Biological Chemistry·2019· 49 citedOpen Access
Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
Nature Communications·2019· 113 citedOpen Access
IMP2 increases mouse skeletal muscle mass and voluntary activity by enhancing autocrine IGF2 production and optimizing muscle metabolism.
Molecular and Cellular Biology·2019· 3 cited
IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism
Molecular and Cellular Biology·2019· 14 citedOpen Access
Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates
F1000Research·2019· 35 citedOpen Access
Faculty Opinions recommendation of mTOR in aging, metabolism, and cancer.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of Cryo-EM structure of human mTOR complex 2.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of mTOR kinase structure, mechanism and regulation.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of Structural basis for the unique biological function of small GTPase RHEB.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of Structure of the human mTOR complex I and its implications for rapamycin inhibition.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
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Frequent Co-authors

John Kyriakis(13), Kenta Hara(8), Kazuyoshi Yonezawa(8), Samuel Long(6), Qing-Ping Weng(5), Mark T. Kozlowski(5), Dawang Zhou(5), Sara Ortiz-Vega(5), James R. Woodgett(4), Noriko Oshiro(4), Chiharu Tokunaga(4), Xianfeng Zhang(4), Hidayat Sujuti(3), Christopher Belham(3), Ulf R. Rapp(3), Nabeel Bardeesy(3), Satoshi Eguchi(3), Kenichi Yoshino(3), Guri Tzivion(3), Papia T. Banerjee(2)