John M. Leong

Tufts University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

66h-index14.4kcitations240works1.82yr avg
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Research Topics

Escherichia coli research studies(61), Vector-borne infectious diseases(55), Bacterial Genetics and Biotechnology(37), Viral gastroenteritis research and epidemiology(35), Viral Infections and Vectors(33)

Publications240 total

Retrospective analysis of <i>Pseudomonas aeruginosa</i> clinical isolates for secreted PrpL protease: a key virulence factor associated with corneal tissue damage
2025Open Access
Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of <i>Borrelia burgdorferi</i> Elp Proteins
Molecular Microbiology·2025· 1 citedOpen Access
Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age‐Dependent Bacteremia Risk Following Pneumococcal Pneumonia
Aging Cell·2025· 1 citedOpen Access
Weakened airway epithelial junctions and enhanced neutrophil elastase release contribute to age-dependent bacteremia risk following pneumococcal pneumonia
2024Open Access
<i>In situ</i> deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic <i>E. coli</i>
PNAS Nexus·2024· 7 citedOpen Access
Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of <i>Borrelia burgdorferi</i> Elp Proteins
2024Open Access
Blocking HXA <sub>3</sub> -mediated neutrophil elastase release during <i>S. pneumoniae</i> lung infection limits pulmonary epithelial barrier disruption and bacteremia
mBio·2024· 5 citedOpen Access
<i>In situ</i> deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic <i>E. coli</i>
2024Open Access
Blocking HXA <sub>3</sub> -mediated neutrophil elastase release during <i>S. pneumoniae</i> lung infection limits pulmonary epithelial barrier disruption and bacteremia
2024Open Access
<i>Streptococcus pneumoniae</i> infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases
2024Open Access
The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi
Journal of Biological Chemistry·2024· 7 citedOpen Access
Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study
Frontiers in Nutrition·2024Open Access
Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study
Frontiers in Nutrition·2023· 1 citedOpen Access
Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination
PLoS Pathogens·2023· 44 citedOpen Access
75 The molecular basis for C1s inhibition by Lyme disease spirochetes
Immunobiology·2023
Pore-forming activity of <i>S. pneumoniae</i> pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin
Infection and Immunity·2023· 12 citedOpen Access
Pore-forming activity of <i>S. pneumoniae</i> pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin
2023Open Access
Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut
Cell Host & Microbe·2023· 116 citedOpen Access
Whole genome sequencing of <i>Borrelia burgdorferi</i> isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence
2023· 1 citedOpen Access
Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s
Journal of Biological Chemistry·2022· 12 citedOpen Access
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Frequent Co-authors

Jenifer Coburn(8), Loranne Magoun(6), Kenneth G. Campellone(5), Martin Teintze(4), Ralph R. Isberg(4), Brian Skehan(4), Nikhat Parveen(4), Douglas R. Robbins(3), Allen C. Steere(3), Michael K. Rosen(3), Joshua R. Fischer(3), Sarah Bodary(3), Yi‐Pin Lin(3), Joseph W. Kloepper(2), M. N. Schroth(2), Vijay Rathinam(2), Sivapriya Kailasan Vanaja(2), Katherine A. Fitzgerald(2), Kishore R. Alugupalli(2), Robert T. Woodland(2)