Steven C. Ley

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index9.7kcitations100works1.32yr avg
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Research Topics

NF-κB Signaling Pathways(36), Immune Response and Inflammation(27), T-cell and B-cell Immunology(18), interferon and immune responses(18), Cytokine Signaling Pathways and Interactions(16)

Publications100 total

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay
EMBO Molecular Medicine·2025Open Access
Bioinformatic analysis of molecular characteristics and oncogenic features of CARD14 in human cancer
Scientific Reports·2024· 2 citedOpen Access
CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation
Biochemical Journal·2024· 3 citedOpen Access
Uncovering CARD14 features in cancer
Research Square (Research Square)·2024Open Access
p38γ and p38δ modulate innate immune response by regulating MEF2D activation
eLife·2023· 6 citedOpen Access
Author response: p38γ and p38δ modulate innate immune response by regulating MEF2D activation
2023Open Access
p38γ and p38δ modulate innate immune response by regulating MEF2D activation
2022Open Access
Correction: TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNFα in LPS-stimulated macrophages
Journal of Cell Science·2022· 2 citedOpen Access
TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages
The Journal of Immunology·2022· 11 citedOpen Access
Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis
Cell Reports·2021· 18 citedOpen Access
TPL‐2 kinase induces phagosome acidification to promote macrophage killing of bacteria
The EMBO Journal·2021· 26 citedOpen Access
CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation
eLife·2020· 29 citedOpen Access
Author response: CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation
2020Open Access
ABIN-2, of the TPL-2 Signaling Complex, Modulates Mammalian Inflammation
Trends in Immunology·2019· 23 cited
Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB
Immunity·2019· 45 citedOpen Access
Endothelial Tpl2 Regulates Vascular Barrier Function Via Tight Junction Protein Claudin-5 Promoting CNS Cell Infiltration and Tumor Metastasis
SSRN Electronic Journal·2019Open Access
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
The Journal of Immunology·2018· 11 citedOpen Access
A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation
The Journal of Experimental Medicine·2018· 20 citedOpen Access
Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate
Biochemical Journal·2017Open Access
Protein CoAlation: a redox-linked post-translational modification
Biochemical Journal·2017· 2 cited
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Frequent Co-authors

Julia Janzen(6), Michaël J. Crumpton(6), Anne O’Garra(5), Monica Belich(4), Stamatia Papoutsopoulou(4), Antony Symons(4), Anthony I. Magee(3), Andrés Salmerón(3), S. Beinke(3), Philip N. Tsichlis(3), Thorsten Gantke(3), Srividya Sriskantharajah(3), Yasmina Soneji(3), Dimitris Kioussis(3), Huei‐Ting Yang(3), Adelina A. Davies(3), R. Huby(3), J. Simon C. Arthur(2), Peter W. Janes(2), Panagiotis S. Kabouridis(2)