Sandra Johannsen

Helmholtz Institute for Pharmaceutical Research Saarland — Germany

Computer Science · Physical Sciences

7h-index399citations19works22.62yr avg
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Research Topics

Computational Drug Discovery Methods(6), Microbial Natural Products and Biosynthesis(6), HIV/AIDS drug development and treatment(3), Carbohydrate Chemistry and Synthesis(3), Cancer therapeutics and mechanisms(3)

Publications17 total

Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Bioorganic Chemistry·2025Open Access
Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS‐CoV‐2
Chemistry - A European Journal·2024· 2 citedOpen Access
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i>
ACS Infectious Diseases·2024· 3 citedOpen Access
Front Cover: Exploring the Translational Gap of a Novel Class of <i>Escherichia coli</i> IspE Inhibitors (ChemMedChem 19/2023)
ChemMedChem·2023Open Access
Exploring the Translational Gap of a Novel Class of <i>Escherichia coli</i> IspE Inhibitors
ChemMedChem·2023· 8 citedOpen Access
Not Every Hit‐Identification Technique Works on 1‐Deoxy‐<scp>d</scp>‐Xylulose 5‐Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
ChemMedChem·2023· 16 citedOpen Access
Target-directed dynamic combinatorial chemistry affords inhibitors of Nsp10 as potential antivirals against SARS-CoV-2
2023Open Access
Identification of three new inhibitor classes against Plasmodium falciparum
2022Open Access
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
2022· 2 citedOpen Access
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
2022Open Access
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
Chemical Science·2022· 17 citedOpen Access
Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy- <scp>d</scp> -xylulose-5-phosphate synthase
Chemical Science·2021· 33 citedOpen Access
Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase
2020· 3 citedOpen Access
Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase
2020Open Access
Research Data Supporting "A Lewis-Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters"
Apollo (University of Cambridge)·2017Open Access
A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters
Angewandte Chemie International Edition·2017· 174 citedOpen Access
A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters
Angewandte Chemie·2017· 33 citedOpen Access

Frequent Co-authors

Anna K. H. Hirsch(14), Robin M. Gierse(9), Jörg Haupenthal(9), Di Zhu(7), Ravindra P. Jumde(5), Rawia Hamid(5), Norbert Reiling(5), Boris Illarionov(5), Mael Poizat(5), Rolf Müller(5), Markus Fischer(5), Alaa Alhayek(4), Tiziana Masini(4), Fabio Lima(3), Lars Grunenberg(3), Joerg Sedelmeier(3), Steven V. Ley(3), Melissa Guardigni(3), Walid A. M. Elgaher(3), Céline Simonin(3)