Charles P. Emerson

University of Massachusetts Chan Medical School — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

67h-index13.1kcitations250works4.72yr avg
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Research Topics

Muscle Physiology and Disorders(72), RNA Research and Splicing(40), RNA and protein synthesis mechanisms(27), RNA modifications and cancer(25), Developmental Biology and Gene Regulation(23)

Publications250 total

A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic
Molecular Therapy — Methods & Clinical Development·2025· 2 citedOpen Access
Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis
iScience·2025Open Access
Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle delivery
2025· 2 citedOpen Access
Increasing intracellular dNTP levels improves prime editing efficiency
Nature Biotechnology·2024· 18 citedOpen Access
SMCHD1 activates the expression of genes required for the expansion of human myoblasts
Nucleic Acids Research·2024· 6 citedOpen Access
SMCHD1 activates the expression of genes required for the expansion of human myoblasts
2024Open Access
A human immune/muscle xenograft model of FSHD muscle pathology
2023· 2 citedOpen Access
Flavones provide resistance to DUX4-induced toxicity via an mTor-independent mechanism
Cell Death and Disease·2023· 4 citedOpen Access
Addressing the dNTP bottleneck restricting prime editing activity
2023· 8 citedOpen Access
Post‐Translational Modifications of the <scp>DUX4</scp> Protein Impact Toxic Function in FSHD Cell Models
Annals of Neurology·2023· 4 citedOpen Access
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration
Nature Communications·2022· 34 citedOpen Access
DUX4 expression activates JNK and p38 MAP kinases in myoblasts
Disease Models & Mechanisms·2022· 15 citedOpen Access
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors
The CRISPR Journal·2022· 49 citedOpen Access
Outcome Measures in Facioscapulohumeral Muscular Dystrophy Clinical Trials
Cells·2022· 25 citedOpen Access
Generation of iMyoblasts from Human Induced Pluripotent Stem Cells
BIO-PROTOCOL·2022· 3 citedOpen Access
iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling
eLife·2021· 28 citedOpen Access
Author response: iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling
2021Open Access
p38 MAPKs — roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets
JCI Insight·2021· 79 citedOpen Access
Data for "iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling"
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Data for "iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling"
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
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Frequent Co-authors

Xingbin Ai(7), Anne‐Gaëlle Borycki(6), Jennifer C. J. Chen(5), Oliver D. King(5), Mary Elizabeth Pownall(4), Marcus K. Gustafsson(4), Kathryn R. Wagner(4), Marion Kusche‐Gullberg(3), Joseph F. Ross(3), Brian P. Brunk(3), Sanford I. Bernstein(3), David J. Goldhamer(3), Natalia A. Riobo‐Del Galdo(2), Ke Lu(2), Gwendolyn M. Haines(2), Anh-Tri Do(2), Ulf Lindahl(2), Stephen F. Konieczny(2), Robert B. Devlin(2), Deborah F. Pinney(2)