Krishan Gopal Thakur

Industrial Research Institute — United States

Medicine · Health Sciences

22h-index1.2kcitations95works3.42yr avg
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Research Topics

Tuberculosis Research and Epidemiology(29), Antibiotic Resistance in Bacteria(16), Bacterial Genetics and Biotechnology(14), Mycobacterium research and diagnosis(11), Biochemical and Molecular Research(10)

Publications95 total

Targeted screening and rational optimization of bazedoxifene analogs as pan-variant SARS-CoV-2 entry inhibitors with improved pharmacokinetics
European Journal of Medicinal Chemistry·2025
The <i>yxiD</i> gene from <i>Bacillus subtilis</i> 6633 encodes a polymorphic toxin with tRNase activity and is neutralized by the cognate immunity protein YxxD
Nucleic Acids Research·2025Open Access
Spike conformational and glycan heterogeneity associated with furin cleavage causes incomplete neutralization of SARS-CoV-2
Nature Communications·2025Open Access
Structural and biophysical insights into RomR, MglB, and MglC interactions involved in regulating cell polarity in Myxococcus xanthus
Journal of Biological Chemistry·2025Open Access
9-fluorenone-based synthetic sulfonamide compounds as dual inhibitors of SARS-CoV-2 Main-Protease and Papain-like Protease
Molecular Diversity·2025· 1 cited
The role of amino acid composition in the antibacterial activity of laterosporulin analogs
Journal of Applied Microbiology·2025
Strategic Design and Optimization of Umifenovir Analogues: Balancing Antiviral Efficacy and hERG Toxicity against SARS-CoV-2
Journal of Medicinal Chemistry·2025· 6 cited
Identification and Characterization of a Novel Protein–Protein Interaction Among SARS‐CoV‐2 Nucleocapsid, Host SFPQ, and hnRNP U and Its Potential Role in Virus Replication
Biology of the Cell·2025Open Access
Discovery of Conformationally Constrained Dihydro Benzo-Indole Derivatives as Metallo-β-Lactamase Inhibitors to Tackle Multidrug-Resistant Bacterial Infections
Journal of Medicinal Chemistry·2025· 4 cited
Conformational and glycan heterogeneity associated with furin cleavage of Spike as a cause of incomplete neutralization of SARS-CoV-2
2025Open Access
Structural insights into Polymorphic toxin–Immunity pair system of <i>Bacillus subtilis</i>
Structural Dynamics·2025Open Access
Itaconate mechanism of action and dissimilation in <i>Mycobacterium tuberculosis</i>
Proceedings of the National Academy of Sciences·2025· 10 citedOpen Access
Structural insights into polymorphic toxin–immunity pair system of <i>Bacillus subtilis</i>
Acta Crystallographica Section A Foundations and Advances·2024Open Access
Mycobacterium tuberculosis strain with deletions in menT3 and menT4 is attenuated and confers protection in mice and guinea pigs
Nature Communications·2024· 7 citedOpen Access
Discovery of Conformationally Constrained Dihydro Benzo-Indole Derivatives as Pan-Metallo-β-Lactamase Inhibitors to Tackle Multidrug-Resistant Bacterial Infections
Research Square (Research Square)·2024Open Access
Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential
PLoS Pathogens·2024· 23 citedOpen Access
Biochemical and structural characterization reveals Rv3400 codes for β‐phosphoglucomutase in <i>Mycobacterium tuberculosis</i>
Protein Science·2024· 6 citedOpen Access
Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity, and neutralization sensitivity
Journal of Virology·2023· 20 citedOpen Access
Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited
Structure·2023· 13 citedOpen Access
Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo
PLoS Pathogens·2023· 8 citedOpen Access
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Frequent Co-authors

Ramandeep Singh(9), Srajan Kapoor(9), Dipesh Kumar Verma(8), Rajesh P. Ringe(7), Amar Deep(6), Soni Kaundal(6), Saqib Kidwai(6), B. Gopal(6), Gundeep Kaur(5), Sakshi Agarwal(4), Rushikesh Tambat(4), Nisha Mahey(4), Nishtha Chandal(4), Hemraj Nandanwar(4), Vipul Solanki(4), Dipak Dutta(4), Sahil Kumar(4), Charandeep Singh(4), Anshul Sharma(3), Deepjyoti Kumar Das(3)