René A. W. van Lier

University Medical Center Utrecht — Netherlands

Immunology and Microbiology · Life Sciences

100h-index31.7kcitations448works2.82yr avg
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Research Topics

T-cell and B-cell Immunology(249), Immune Cell Function and Interaction(248), Immunotherapy and Immune Responses(115), Cytomegalovirus and herpesvirus research(75), Monoclonal and Polyclonal Antibodies Research(55)

Publications446 total

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS‐CoV‐2‐Specific CD8 <sup>+</sup> T Cell Responses
European Journal of Immunology·2025Open Access
Author response for "Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS‐CoV‐2‐Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Responses"
2025
Author response for "Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS‐CoV‐2‐Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Responses"
2024
NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells
Cell Reports·2024· 11 citedOpen Access
Two sides of the same coin: Protective versus pathogenic CD4 <sup>+</sup> resident memory T cells
Science Immunology·2022· 32 cited
Hobit and Blimp‐1 regulate T<sub>RM</sub> abundance after LCMV infection by suppressing tissue exit pathways of T<sub>RM</sub>precursors
European Journal of Immunology·2022· 26 citedOpen Access
Allo-reactive tissue-resident T cells causing damage: An inside job
The Journal of Experimental Medicine·2022· 2 citedOpen Access
Polyfunctional pathogen-specific CD4 <sup>+</sup> T cells reside in the lungs and tumors of NSCLC patients
2022· 2 citedOpen Access
Single-Cell Transcriptomics Reveals Discrete Steps in Regulatory T Cell Development in the Human Thymus
The Journal of Immunology·2021· 22 citedOpen Access
Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment
European Journal of Immunology·2021· 9 citedOpen Access
Author response for "Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment"
2021
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial
Trials·2021· 20 citedOpen Access
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes
Science Immunology·2021· 91 cited
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial
Trials·2021· 23 citedOpen Access
How to Reliably Define Human CD8<sup>+</sup>T-Cell Subsets: Markers Playing Tricks
Cold Spring Harbor Perspectives in Biology·2021· 6 citedOpen Access
CD8 and CD4 T Cell Populations in Human Kidneys
Cells·2021· 25 citedOpen Access
Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands
Nature Communications·2020· 98 citedOpen Access
Divergent SARS‐CoV‐2‐specific T‐ and B‐cell responses in severe but not mild COVID‐19 patients
European Journal of Immunology·2020· 145 citedOpen Access
Author response for "Divergent SARS‐CoV‐2‐specific T and B cell responses in severe but not mild COVID‐19 patients"
2020· 1 cited
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses
Nature Immunology·2020· 170 citedOpen Access
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Frequent Co-authors

Ineke J. M. ten Berge(11), Paul A. Baars(10), Ester B. M. Remmerswaal(8), Kiki Tesselaar(6), Taco W. Kuijpers(6), Dörte Hamann(5), Jannie Borst(5), Susanne M.A. Lens(5), Regina Stark(4), Klaas P. J. M. van Gisbergen(4), Pleun Hombrink(4), René E. Jonkers(4), Laila E. Gamadia(4), Jan Weel(4), Jörg Hamann(4), Ester M. M. van Leeuwen(4), Rogier Q. Hintzen(4), Ramon Arens(4), Berend Hooibrink(3), Berber Piet(3)