Patrick Markt

Austrian Academy of Sciences — Austria

Computer Science · Physical Sciences

28h-index2.1kcitations51works0.02yr avg
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Research Topics

Computational Drug Discovery Methods(18), Peroxisome Proliferator-Activated Receptors(8), Neuroendocrine regulation and behavior(7), Receptor Mechanisms and Signaling(6), Protein Structure and Dynamics(5)

Publications51 total

Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex
Translational Psychiatry·2017· 92 citedOpen Access
A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor
Nature Chemical Biology·2017· 50 cited
Abstract LB-099: A high-throughput screen of approved drugs uncovers a synergistic interaction targeting prostate cancer
Cancer Research·2015
Enriched environment impacts trimethylthiazoline‐induced anxiety‐related behavior and immediate early gene expression: critical role of<i><scp>C</scp>rhr1</i>
European Journal of Neuroscience·2014· 10 cited
Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala
Translational Psychiatry·2014· 49 citedOpen Access
Real-Time Imaging of Amygdalar Network Dynamics<i>In Vitro</i>Reveals a Neurophysiological Link to Behavior in a Mouse Model of Extremes in Trait Anxiety
Journal of Neuroscience·2013· 16 citedOpen Access
Interaction of genetic predisposition and epigenetic factors in the development of anxiety
Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)·2013· 3 citedOpen Access
CLOUD – CeMM library of unique drugs
Journal of Cheminformatics·2012· 2 citedOpen Access
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach
European Journal of Medicinal Chemistry·2012· 62 citedOpen Access
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B
European Journal of Medicinal Chemistry·2011· 43 citedOpen Access
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation
Bioorganic & Medicinal Chemistry·2011· 48 citedOpen Access
Differences in intrinsic amygdalar network features between animals of the high- vs. low-anxiety-related behavior (HAB, LAB) mouse model
Pharmacopsychiatry·2011
Adult neurogenesis in a mouse model of affective behavior: pharmacological and non-pharmacological interventions
Pharmacopsychiatry·2011
Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein
Atherosclerosis·2011· 42 citedOpen Access
Genetic predisposition to anxiety-related behavior predicts predator odor response
Behavioural Brain Research·2011· 28 cited
Virtual Screening Against Obesity
Current Medicinal Chemistry·2011· 3 cited
Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E<sub>2</sub> Synthase-1 (mPGES-1)
Journal of Medicinal Chemistry·2011· 53 citedOpen Access
Alizarine derivatives as new dual inhibitors of the HIV‐1 reverse transcriptase‐associated DNA polymerase and RNase H activities effective also on the RNase H activity of non‐nucleoside resistant reverse transcriptases
FEBS Journal·2011· 34 citedOpen Access
Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening
The Journal of Steroid Biochemistry and Molecular Biology·2011· 37 cited
Development of Anti-Viral Agents Using Molecular Modeling and Virtual Screening Techniques
Infectious Disorders - Drug Targets·2011· 55 cited
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Frequent Co-authors

Gerhard Wolber(27), Johannes Kirchmair(24), Thierry Langer(20), Daniela Schuster(20), Simona Distinto(19), Gudrun M. Spitzer(13), Judith M. Rollinger(10), Klaus R. Liedl(9), Hermann Stuppner(9), Rainer Landgraf(8), Christian Laggner(8), Sergey Sotnikov(5), Elias Maccioni(5), Stefan Schwaiger(4), Herta Flor(4), Maria Cristina Cardia(4), Stefano Alcaro(4), Jürg Gertsch(3), Stefan Raduner(3), Rasmus K. Petersen(3)