Magdalena M. Szewczyk

University of Toronto — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index3.8kcitations109works8.42yr avg
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Research Topics

Epigenetics and DNA Methylation(39), Cancer-related gene regulation(37), Protein Degradation and Inhibitors(22), Ubiquitin and proteasome pathways(21), Peptidase Inhibition and Analysis(14)

Publications109 total

Development of a dual chemical probe for the USP16 and HDAC6 zinc-finger ubiquitin-binding domain
2025Open Access
OICR-41103 as a chemical probe for the DCAF1 WD40 domain
Communications Biology·2025Open Access
Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells
Nature Communications·2025· 3 citedOpen Access
ABHD2 activity is not required for the non-genomic action of progesterone on human sperm
2024Open Access
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity
Nature Communications·2024· 27 citedOpen Access
Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells
2024Open Access
Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells
2024· 2 citedOpen Access
Recruitment of FBXO22 for targeted degradation of NSD2
Nature Chemical Biology·2024· 47 citedOpen Access
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity
2024· 1 citedOpen Access
A chemical probe to modulate human GID4 Pro/N-degron interactions
Nature Chemical Biology·2024· 20 cited
Probing the CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons
PNAS Nexus·2024· 4 citedOpen Access
A new method for the purification of bioviable NEU1 sialidase for enzyme replacement therapy for sialidosis
Molecular Genetics and Metabolism·2024
Designing Sustainable Ethanol Oxidation Catalysts: The Role of Graphene Oxide in NiCuGO Composite Material
Energies·2024· 2 citedOpen Access
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
RSC Medicinal Chemistry·2024· 12 citedOpen Access
Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations
Experimental Hematology·2023· 5 citedOpen Access
Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration
ACS Medicinal Chemistry Letters·2023· 13 citedOpen Access
Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations
2023Open Access
Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex
2023· 6 citedOpen Access
Recruitment of FBXO22 for Targeted Degradation of NSD2
2023· 4 citedOpen Access
Probing the DCAF12 interactions with MAGEA3 and CCT5 C-terminal degrons
2023Open Access
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Frequent Co-authors

Dalia Baršytė-Lovejoy(38), C.H. Arrowsmith(35), Masoud Vedadi(28), Fengling Li(23), Peter J. Brown(23), Matthieu Schapira(16), Mohammad S. Eram(13), Aiping Dong(10), Vijayaratnam Santhakumar(9), Jian Jin(8), David Dilworth(8), Sidney H. Kennedy(7), Renato Ferreira de Freitas(7), David Smil(7), Levon Halabelian(7), Abdellah Allali‐Hassani(7), Ashok K. Grover(6), Yudao Shen(6), Victoria Vu(6), Jyoti Pande(5)