Mark D. Rekhter

Eli Lilly (United States) — United States

Medicine · Health Sciences

29h-index8.2kcitations66works0.02yr avg
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Research Topics

Cell Adhesion Molecules Research(16), Atherosclerosis and Cardiovascular Diseases(14), Protease and Inhibitor Mechanisms(10), Coronary Interventions and Diagnostics(7), Adipokines, Inflammation, and Metabolic Diseases(7)

Publications66 total

Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation
Frontiers in Physiology·2020· 8 citedOpen Access
Selective Phosphodiesterase 1 Inhibitor LY1 Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats
The FASEB Journal·2020
Abstract 100: Dual Activation of PKA and PKG by PDE1 Inhibition Facilitates Proteasomal Degradation of Misfolded Proteins and Protects Against Proteinopathy-Based HFpEF
Circulation Research·2019
PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy
Science Advances·2019· 68 citedOpen Access
Duo-activation of PKA and PKG by PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against proteinopathy
2019· 2 citedOpen Access
Inhibition of Type 1 Phosphodiesterse Confers Therapeutic Benefit to Proteinopathy‐based HFpEF in Mice
The FASEB Journal·2018
Factors associated with stroke, myocardial infarction, ischemic heart disease, unstable angina, or mortality in patients from real world clinical practice with newly-diagnosed type 2 diabetes and early glycemic control
Current Medical Research and Opinion·2017· 18 cited
IDENTIFYING RISK FACTORS ASSOCIATED WITH STROKE, MYOCARDIAL INFARCTION, ISCHEMIC HEART DISEASE, AND UNSTABLE ANGINA IN NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS PATIENTS
Value in Health·2016Open Access
PREDICTORS OF MORTALITY AND CARDIOVASCULAR EVENTS IN PATIENTS NEWLY DIAGNOSED WITH TYPE 2 DIABETES MELLITUS
Value in Health·2016
PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis
Cardiovascular Research·2015· 70 citedOpen Access
Reverse translation in cardiovascular drug discovery
Journal of Clinical & Experimental Cardiology·2014
Concordant Changes of Plasma and Kidney MicroRNA in the Early Stages of Acute Kidney Injury: Time Course in a Mouse Model of Bilateral Renal Ischemia-Reperfusion
PLoS ONE·2014· 44 citedOpen Access
Glucose Metabolic Trapping in Mouse Arteries: Nonradioactive Assay of Atherosclerotic Plaque Inflammation Applicable to Drug Discovery
PLoS ONE·2012· 9 citedOpen Access
Hyperinsulinemia Does Not Change Atherosclerosis Development in Apolipoprotein E Null Mice
Arteriosclerosis Thrombosis and Vascular Biology·2012· 33 citedOpen Access
Protein Kinase C inhibition ameliorates functional endothelial insulin resistance and Vascular Smooth Muscle Cell hypersensitivity to insulin in diabetic hypertensive rats
Cardiovascular Diabetology·2011· 27 citedOpen Access
Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice
Cell Metabolism·2010· 295 citedOpen Access
Chemical analysis of atherosclerotic plaque cholesterol combined with histology of the same tissue
Journal of Lipid Research·2008· 15 citedOpen Access
Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation
Biochemical and Biophysical Research Communications·2008· 42 cited
Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice
Biomarker Insights·2008· 1 citedOpen Access
Immunohistochemical analysis of target proteins of Rho-kinase in a mouse model of accelerated atherosclerosis.
PubMed·2007· 23 citedOpen Access
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Frequent Co-authors

David J. Gordon(11), Erick Kindt(5), Wendy S. Rosebury(4), James S. Bean(4), Peter Libby(3), S. Ward Casscells(3), John A. Rumberger(3), Zahi A. Fayad(3), James E. Muller(3), George L. King(3), Sotirios K. Karathanasis(3), Valeri Kolpakov(3), Robert D. Simari(3), Gary J. Nabel(3), Carolyn Work(3), Hussein Hallak(3), Е. Р. Андреева(3), Alexander A. Mirоnоv(3), Alexander N. Orekhov(3), Pamela Rutherford(3)