Norman J. Oppenheimer

University of California, San Francisco — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index5.4kcitations121works0.02yr avg
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Research Topics

Calcium signaling and nucleotide metabolism(33), PARP inhibition in cancer therapy(23), DNA and Nucleic Acid Chemistry(17), Adenosine and Purinergic Signaling(15), Toxin Mechanisms and Immunotoxins(15)

Publications121 total

Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD+
DNA repair·2014· 4 cited
Insights into the Mechanism of Bovine CD38/NAD+Glycohydrolase from the X-Ray Structures of Its Michaelis Complex and Covalently-Trapped Intermediates
PLoS ONE·2012· 31 citedOpen Access
<scp>NAD</scp><sup>+</sup>and<scp>NADP</scp><sup>+</sup>as Prosthetic Groups for Enzymes
Encyclopedia of Life Sciences·2010· 8 cited
Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38
Journal of Biological Chemistry·2009· 82 citedOpen Access
Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase
Journal of Biological Chemistry·2009· 57 citedOpen Access
Crystal structure of human CD38 complexed with an analog ara-2'F-ADPR
2009
Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose
2009
Crystal structure of ADP ribosyl cyclase complexed with N1-cIDPR
2009
Crystal structure of ADP ribosyl cyclase complexed with substrate NAD
2009
Structural Basis for Enzymatic Mechanisms of ADP-ribosyl Cyclase
2009
CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism
International Immunology·2006· 35 cited
Activation of T Cell Calcium Influx by the Second Messenger ADP-ribose
Journal of Biological Chemistry·2005· 115 citedOpen Access
CD38 Controls ADP-Ribosyltransferase-2-Catalyzed ADP-Ribosylation of T Cell Surface Proteins
The Journal of Immunology·2005· 89 citedOpen Access
Extracellular NAD+ regulates intracellular free calcium concentration in human monocytes
Biochemical Journal·2004· 36 citedOpen Access
Regulation of Dendritic Cell Trafficking by the ADP-Ribosyl Cyclase CD38
Immunity·2004· 204 citedOpen Access
CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes
European Journal of Biochemistry·2004· 25 citedOpen Access
Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose
The Journal of Immunology·2004· 102 citedOpen Access
Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases
Journal of Biological Chemistry·2003· 237 citedOpen Access
Fluorometric studies of ligand-induced conformational changes of CD38
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2003· 9 cited
Novel Hydrolysis-Resistant Analogues of Cyclic ADP-ribose:  Modification of the “Northern” Ribose and Calcium Release Activity
Biochemistry·2002· 37 cited
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Frequent Co-authors

Sidney M. Hecht(7), Luis O. Rodriguez(6), Nathan O. Kaplan(6), Francis Schuber(6), Frances E. Lund(5), Hélène Muller‐Steffner(5), Santiago Partida‐Sánchez(4), Guy M. Ehrenfeld(3), Joel Moss(3), Anthony L. Handlon(3), Céline Cakir‐Kiefer(3), Kim Kusser(2), Stephen Goodrich(2), Troy D. Randall(2), P. F. Crain(2), J. A. MCCLOSKEY(2), Karin Weber(2), Andreas H. Guse(2), Miguel E. Moreno‐García(2), Lyle J. Arnold(2)