Niilo T. Kärki

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

22h-index1.5kcitations81works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(23), Drug Transport and Resistance Mechanisms(11), Carcinogens and Genotoxicity Assessment(9), Eicosanoids and Hypertension Pharmacology(7), Drug-Induced Hepatotoxicity and Protection(6)

Publications81 total

Crystal structure of pigeon Cryptochrome 4 mutant Y319D in complex with flavin adenine dinucleotide
2019· 1 cited
Polymorphism of debrisoquine hydroxylation among Finns and Lapps.
British Journal of Clinical Pharmacology·1988· 18 citedOpen Access
Cardiovascular and sedative alpha-adrenoceptor effects of detomidine-like arylalkyl imidazoles and associated derivatives.
PubMed·1988· 6 cited
Mono-oxygenase catalyzed reactions and binding of benzo(a)pyrene to DNA in human tissues. Role in susceptibility to chemically induced cancer
European Journal of Cancer and Clinical Oncology·1987
The Metabolism of 2,5‐Diphenyloxazole (PPO) in Human Lymphocytes and Rat Liver Microsomes
Pharmacology & Toxicology·1987· 5 cited
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls
International Journal of Cancer·1987· 54 cited
Hepatic drug metabolism and the activities of NADPH generating enzymes and glucose-6-phosphatase in phenobarbital treated genetically obese (ob/ob) mice.
PubMed·1987· 7 cited
EVIDENCE FOR MEDETOMIDINE AS A SELECTIVE AND POTENT AGONIST α<sub>2</sub>‐ADRENORECEPTORS
Journal of Autonomic Pharmacology·1986· 146 cited
Increased sister-chromatid exchange rate and its regression during prolonged incubation in lymphocyte cultures from patients with multiple sclerosis
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis·1986· 8 cited
Re-evaluation of drug-interaction with α-adrenoceptors and using imidazole derivatives
Life Sciences·1986· 6 cited
Cytogenic Effects of a Novel Antiestrogen Toremifene FC-1157a: A Comparison with Diethylstilbestrol and Tamoxifen
Archives of toxicology. Supplement·1986· 2 cited
Cardiovascular action of detomidine, a sedative and analgesic imidazole derivative with α-agonistic properties
European Journal of Pharmacology·1985· 12 cited
Metabolism of Medroxyprogesterone Acetate and Hepatic Drug Metabolism Activity
The Journal of Urology·1985· 8 cited
Peripheral cardiovascular α- and β-adrenergic effects of some hypotensive and bradycardic arylalkyl imidazole derivatives in the rat
Journal of Pharmacy and Pharmacology·1985· 4 cited
Genetic and Environmental Regulation of Aryl Hydrocarbon Hydroxylase in Man: Studies with Liver, Lung, Placenta, and Lymphocytes
Toxicologic Pathology·1984· 22 cited
Medroxyprogesterone acetate improvement of the hepatic drug-metabolizing enzyme system in rats after chemical liver injury
Biochemical Pharmacology·1983· 6 cited
A relationship between cord blood and maternal blood lymphocytes and term placenta in the induction of aryl hydrocarbon hydroxylase activity
Cancer Letters·1981· 13 cited
Aryl Hydrocarbon Hydroxylase Induction in Maternal and CordBlood Mitrogen-Treated Lymphocytes
Developmental Pharmacology and Therapeutics·1981· 8 cited
Dose-dependent effects of medroxyprogesterone acetate on the hepatic drug-metabolizing enzyme system in rats
Biochemical Pharmacology·1980· 11 cited
Effects of Various<i>in Vitro</i>‐ inhibitors of Benzo(a)pyrene Metabolism in Isolated Rat Lung Perfusion
Acta Pharmacologica et Toxicologica·1979· 10 cited
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Frequent Co-authors

Olavi Pelkonen(24), Jorma T. Ahokas(6), P. Arvela(5), M. K. Paasonen(5), Juha‐Matti Savola(4), Heikki Ruskoaho(4), Juhani Puurunen(4), Eero H. Kaltiala(4), Pentti Jouppila(4), Hannu U. Saarni(4), T. K. I. Larmi(3), Kirsi Vähäkangas(3), Risto Tuimala(3), Eero A. Sotaniemi(3), Jari Stengård(3), J. S. Salonen(2), Kaisu Nevasaari(2), Maila Koivisto(2), Antti Kauppila(2), M. Kirjarinta(2)