Trevor Doyle

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index463citations49works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(30), Neurotransmitter Receptor Influence on Behavior(21), Computational Drug Discovery Methods(9), Neuropeptides and Animal Physiology(7), Neuroscience and Neuropharmacology Research(4)

Publications49 total

Identification and Characterization of ML321: A Novel and Highly Selective D <sub>2</sub> Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity
ACS Pharmacology & Translational Science·2022· 4 citedOpen Access
Identification and Characterization of ML321: a Novel and Highly Selective D <i>2</i> Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity
2022Open Access
1728P Clinical practice audit on prescribing frequency of buccal midazolam in patients with high grade gliomas
Annals of Oncology·2021
Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening
Cells·2019· 34 citedOpen Access
Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia
Biochemical Pharmacology·2019· 44 citedOpen Access
At the Intersection Between Mitochondrial Dysfunction and Lysosomal Autophagy: Role of PD-Related Neurotoxins and Gene Products
2017
Optimization of a Novel D <sub>2</sub> Dopamine Receptor Antagonist Scaffold Reveals Exceptionally Selective and Potent Lead Molecules
The FASEB Journal·2017
Discovery and Optimization of ML417: A Potent and Highly Selective D <sub>3</sub> Dopamine Receptor Agonist
The FASEB Journal·2017
Comparative pharmacological characterization of D1-like dopamine receptors from Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages
Parasites & Vectors·2016· 21 citedOpen Access
Identifying new players and pathways involved in receptor‐mediated heterologous sensitization of adenylyl cyclase using genome‐wide siRNA and BiFC library screening
The FASEB Journal·2016
Identification and characterization of a novel dopamine receptor antagonist with high selectivity for the D <sub>2</sub> dopamine receptor
The FASEB Journal·2016
Identification of a novel dopaminergic agonist that displays locational bias and functional selectively at the D <sub>2</sub> dopamine receptor
The FASEB Journal·2015
Dopamine Receptor Antagonists as New Mode-of-Action Insecticide Leads for Control of Aedes and Culex Mosquito Vectors
PLoS neglected tropical diseases·2015· 45 citedOpen Access
Structural basis for Na<sup>+</sup>-sensitivity in dopamine D2 and D3 receptors
Chemical Communications·2015· 35 citedOpen Access
Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists
European Neuropsychopharmacology·2014· 23 citedOpen Access
Evaluation of AaDOP2 Receptor Antagonists Reveals Antidepressants and Antipsychotics as Novel Lead Molecules for Control of the Yellow Fever Mosquito, Aedes aegypti
Journal of Pharmacology and Experimental Therapeutics·2014· 16 citedOpen Access
(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling
Psychopharmacology·2014· 27 citedOpen Access
Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor
Molecular Pharmacology·2014· 83 citedOpen Access
Identification of allosteric modulators of the D <sub>2</sub> dopamine receptor (662.6)
The FASEB Journal·2014
High‐throughput screening for novel allosteric modulators of the D1 dopamine receptor (662.4)
The FASEB Journal·2014
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Frequent Co-authors

David R. Sibley(40), R. Benjamin Free(39), Jennie Conroy(30), Noel Southall(28), Marc Ferrer(26), Juan Marugán(22), Steve Titus(18), Jingbo Xiao(17), Elena Barnaeva(17), Marthe Bryant-Genevier(16), Mercedes K. Taylor(16), Wei Zheng(14), Jonathan A. Javitch(12), Amy E. Moritz(10), Val J. Watts(9), Xin Hu(7), Andrés E. Dulcey(6), Lani S. Chun(5), Brittney Miller(5), Julie A. Meade(4)