Stephen B. Liggett

University of South Florida — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

86h-index26.7kcitations341works3.12yr avg
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Research Topics

Receptor Mechanisms and Signaling(200), Asthma and respiratory diseases(68), Neuropeptides and Animal Physiology(63), Pharmacological Effects and Assays(59), Biochemical Analysis and Sensing Techniques(32)

Publications340 total

The transcriptome of CD14 <sup>+</sup> CD163 <sup>-</sup> HLA-DR <sup>low</sup> monocytes predicts mortality in Idiopathic Pulmonary Fibrosis
European Respiratory Journal·2025
The transcriptome of CD14+CD163-HLA-DRlow monocytes predicts mortality in Idiopathic Pulmonary Fibrosis
2025
β <sub>1</sub> - and β <sub>2</sub> -adrenergic Receptor Haplotypes Regulate Therapeutic Responses to Placebo and the Biased Ligand β-blocker Bucindolol
2025Open Access
TAS2R5 screening reveals biased agonism that fails to evoke internalization and downregulation resulting in attenuated desensitization
PLoS ONE·2025· 1 citedOpen Access
BPS2025 - Structural modeling and selective ligand design for TAS2R10 to unveil therapeutic targets
Biophysical Journal·2025
Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5
Proceedings of the National Academy of Sciences·2024· 6 citedOpen Access
Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators
Nature Communications·2024· 15 citedOpen Access
The transcriptome of CD14 <sup>+</sup> CD163 <sup>-</sup> HLA-DR <sup>low</sup> monocytes predicts mortality in Idiopathic Pulmonary Fibrosis
2024· 3 citedOpen Access
Author Correction: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics
Communications Biology·2023Open Access
How carvedilol does not activate β2-adrenoceptors
Nature Communications·2023· 11 citedOpen Access
Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators
2023· 1 citedOpen Access
An extensive β1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies
JCI Insight·2023· 6 citedOpen Access
Non-genetic Insights Into the Functional Efficacy of β2-adrenoreceptors in Human Airway Smooth Muscle Cells Through the Lens of Bitter Taste Receptors
2023
The Relaxation Effect of Pitavastatin on Human Airway Smooth Muscle Cells: A Role for Acute F-actin Disruption
2023
Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes
iScience·2023· 28 citedOpen Access
Coordinates of Agonist-bound TAS2R14 Structures
Harvard Dataverse·2023Open Access
A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14
American Journal of Respiratory Cell and Molecular Biology·2023· 14 citedOpen Access
Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development
Molecular Diagnosis & Therapy·2022· 12 citedOpen Access
α<sub>1B/D</sub>-adrenoceptors regulate chemokine receptor–mediated leukocyte migration via formation of heteromeric receptor complexes
Proceedings of the National Academy of Sciences·2022· 11 citedOpen Access
Peripheral Blood Gene Expression Changes Predict Mortality and Treatment Response in Acute Covid-19 and Associate with Lung Fibrosis
2022· 2 cited
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Frequent Co-authors

Gerald W. Dorn(9), John N. Lorenz(5), Scott T. Weiss(5), J Turki(4), Stephen P. Peters(4), Kersten M. Small(4), Lynne E. Wagoner(4), Marc G. Caron(4), Robert J. Lefkowitz(4), Dennis W. McGraw(3), Stuart A. Green(3), Michael A. Innis(3), Yoshihito Sakata(3), Richard A. Walsh(3), Elliot Israel(3), Richard J. Martin(3), Jeffrey M. Drazen(3), M T Jacinto(3), Harvey S. Hahn(3), Margaret G. Eason(3)