D. James Surmeier

Northwestern University — United States

Neuroscience · Life Sciences

104h-index39.7kcitations331works8.62yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(169), Neurological disorders and treatments(103), Parkinson's Disease Mechanisms and Treatments(99), Ion channel regulation and function(53), Neurotransmitter Receptor Influence on Behavior(45)

Publications330 total

State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
Science Advances·2025Open Access
Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment
Frontiers in Cell and Developmental Biology·2025Open Access
The role of mesolimbic circuitry in aversive signaling and opioid dependence
Neuron·2025· 1 cited
Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment
2025Open Access
Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use
Science Advances·2025· 13 citedOpen Access
Intranasal administration of isradipine preferentially targets the brain
2025Open Access
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
2025· 4 citedOpen Access
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Molecular Neurodegeneration·2024· 47 citedOpen Access
Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports
Nature Communications·2024· 27 citedOpen Access
Correction: GABAergic regulation of striatal spiny projection neurons depends upon their activity state
PLoS Biology·2024· 1 citedOpen Access
Author Correction: Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson’s disease
npj Parkinson s Disease·2024Open Access
Research Priorities on the Role of α‐ <scp>Synuclein</scp> in Parkinson's Disease Pathogenesis
Movement Disorders·2024· 22 citedOpen Access
Ca <sup>2+</sup> -dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
2024Open Access
Tonic dendritic GABA release by substantia nigra dopaminergic neurons
2024· 2 citedOpen Access
Correction: Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice
Molecular Psychiatry·2024Open Access
Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice
Molecular Psychiatry·2024· 10 citedOpen Access
Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson’s disease
npj Parkinson s Disease·2024· 10 citedOpen Access
GABAergic regulation of striatal spiny projection neurons depends upon their activity state
PLoS Biology·2024· 27 citedOpen Access
Source data for "α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease"
Zenodo (CERN European Organization for Nuclear Research)·2024Open Access
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
2023· 9 citedOpen Access
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Frequent Co-authors

Jaime N. Guzmán(9), Tatiana Tkatch(9), Paul Greengard(8), Michelle Day(8), C. Savio Chan(7), Ema Ilijić(7), Jun Ding(6), Zhong Xie(5), Paul T. Schumacker(5), Tracy S. Gertler(5), Weixing Shen(4), Javier Sánchez-Padilla(4), David L. Wokosin(4), Jyothisri Kondapalli(4), Joshua L. Plotkin(4), Zhongfeng Wang(3), Wen‐Jie Song(3), Eric J. Nestler(3), Salvador Hernández‐López(3), Luis Carrillo‐Reid(2)