Nitin D. Mehta

Mayo Clinic — United States

Medicine · Health Sciences

18h-index2.3kcitations22works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(8), Parkinson's Disease Mechanisms and Treatments(4), Neurological diseases and metabolism(4), Computational Drug Discovery Methods(3), RNA and protein synthesis mechanisms(3)

Publications22 total

Sensitization of Neuronal Cells to Oxidative Stress with Mutated Human α‐Synuclein
Journal of Neurochemistry·2000· 87 cited
Distinctive neuropathology revealed by α-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p
Acta Neuropathologica·2000· 174 cited
Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitiZe SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis
Neuroscience·1999· 42 cited
Antisense‐Induced Reduction of Presenilin 1 Expression Selectively Increases the Production of Amyloid β42 in Transfected Cells
Journal of Neurochemistry·1999· 45 cited
Widespread Alterations of α-Synuclein in Multiple System Atrophy
American Journal Of Pathology·1999· 305 citedOpen Access
The N54 mutant of Gα<sub>s</sub> has a conditional dominant negative phenotype which suppresses hormone‐stimulated but not basal cAMP levels
FEBS Letters·1999· 18 cited
Truncated presenilin 2 derived from differentially spliced mRNAs does not affect the ratio of amyloid β-peptide 1-42/1-40
Neuroreport·1998· 17 cited
ANTIBODIES TO NON-AMYLOID COMPONENT OF PLAQUES (NACP) SPECIFICALLY LABEL LEWY BODIES AND LEWY NEURITES, BUT NOT OTHER INCLUSIONS IN NEURODEGENERATIVE DISEASES
Journal of Neuropathology & Experimental Neurology·1998· 7 cited
Cloning and characterization of the presenilin-2 gene promoter
Molecular Brain Research·1998· 22 cited
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
Nature Medicine·1998· 346 cited
Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
Annals of Neurology·1998· 102 cited
A New Pathogenic Mutation in the APP Gene (I716V) Increases the Relative Proportion of A 42(43)
Human Molecular Genetics·1997· 227 citedOpen Access
Alterations in macrophage G proteins are associated with endotoxin tolerance
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·1996· 32 cited
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
Nature Genetics·1995· 470 cited
Gi is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells.
Molecular Pharmacology·1995· 23 cited
Bovine Brain GO Isoforms Have Distinct γ Subunit Compositions
Journal of Biological Chemistry·1995· 38 citedOpen Access
Proenkephalin gene expression in testicular interstitial cells is down-regulated coincident with the appearance of pachytene spermatocytes.
Endocrinology·1994· 10 cited
Analysis of G protein gamma subunit heterogeneity using mass spectrometry.
Journal of Biological Chemistry·1994· 21 citedOpen Access
Selective transcription of rat proenkephalin fusion genes from the spermatogenic cell-specific promoter in testis of transgenic mice.
Journal of Biological Chemistry·1991· 26 citedOpen Access
Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.
Proceedings of the National Academy of Sciences·1990· 144 citedOpen Access
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Frequent Co-authors

John Hardy(10), Jordi Pérez‐Tur(7), Matthew J. Farrer(5), John D. Hildebrandt(5), Dennis W. Dickson(4), M. Hutton(3), Richard Crook(3), S. -H. Yen(3), Chris Eckman(3), Guy Prihar(2), Matt Baker(2), Karen Duff(2), Henry Houlden(2), Richard F. Cowburn(2), Bengt Winblad(2), Matti Haltia(2), Minna Pöyhönen(2), Katrina Gwinn(2), Debra Yager(2), Steve Younkin(2)