Ryan M. Pelis

Novartis (Switzerland) — Switzerland

Medicine · Health Sciences

21h-index1.3kcitations60works2.32yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(35), Pharmacological Effects and Toxicity Studies(14), Aquaculture Nutrition and Growth(8), Physiological and biochemical adaptations(8), Amino Acid Enzymes and Metabolism(8)

Publications60 total

Primary Small Intestinal Epithelia Are Physiological Alternatives to the Caco-2 Lymphatic Transport Model
Molecular Pharmaceutics·2025· 1 cited
Improving accuracy in food effect predictions: Application of in-vitro absorption experiments as a useful tool for the evaluation of ten drug products
European Journal of Pharmaceutics and Biopharmaceutics·2025· 1 cited
Physiologically based pharmacokinetic modeling of midostaurin and metabolites at steady-state to bridge drug interaction scenarios in lieu of clinical trials
Drug Metabolism and Disposition·2025· 4 cited
Utility of an <i>in vitro</i> lymphatics on-chip model for rank ordering subcutaneous absorption of monoclonal antibodies
Lab on a Chip·2025· 3 citedOpen Access
Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions
Journal of Xenobiotics·2023· 2 citedOpen Access
Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia
International Journal of Molecular Sciences·2022· 9 citedOpen Access
Tissue and salinity specific Na+/Cl− cotransporter (NCC) orthologues involved in the adaptive osmoregulation of sea lamprey (Petromyzon marinus)
Scientific Reports·2021· 16 citedOpen Access
Tissue- and Salinity-specific Na–Cl Cotransporter (NCC) Orthologues Involved in the Sea lamprey (Petromyzon Marinus) Adaptive Osmoregulation
Research Square (Research Square)·2021· 1 citedOpen Access
Quantitative Proteomics and Mechanistic Modeling of Transporter‐Mediated Disposition in Nonalcoholic Fatty Liver Disease
Clinical Pharmacology & Therapeutics·2019· 75 cited
Fluorescent organic cations for human OCT2 transporters screening: uptake in CHO cells stably expressing hOCT2
ADMET & DMPK·2017· 4 citedOpen Access
MRP4 Influences cAMP Levels in Ciliary Epithelial cells of the Human Eye
The FASEB Journal·2017
ClC Channels and Transporters: Structure, Physiological Functions, and Implications in Human Chloride Channelopathies
Frontiers in Pharmacology·2017· 108 citedOpen Access
Influence of age on intestinal bile acid transport in C57BL/6 mice
Pharmacology Research & Perspectives·2017· 11 citedOpen Access
Drug Transport by the Blood–Aqueous Humor Barrier of the Eye
Drug Metabolism and Disposition·2016· 70 cited
Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines
Frontiers in Pharmacology·2015· 14 citedOpen Access
Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange
Drug Metabolism and Disposition·2015· 17 cited
Re‐investigation into the Ligand Selectivity of OAT2
The FASEB Journal·2015
A Renal-Like Organic Anion Transport System in the Ciliary Epithelium of the Bovine and Human Eye
Molecular Pharmacology·2015· 7 citedOpen Access
Cystic fibrosis transmembrane conductance regulator dysfunction in VIP knockout mice
American Journal of Physiology-Cell Physiology·2014· 16 citedOpen Access
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Frequent Co-authors

Stephen H. Wright(11), J. Larry Renfro(6), Stephen D. McCormick(5), Mohammad Shahidullah(5), Nicholas A. Delamere(5), Leslie Ingraham(5), Mansong Li(5), Adam Hotchkiss(5), Theresa M. Wunz(4), Yodying Dangprapai(3), Miguel Coca‐Prados(3), Imad Hanna(3), Bethzaida Astorga(3), Diogo R. Poroca(2), Valérie Chappe(2), Yaofeng Cheng(2), Arpine Vapurcuyan(2), Lauren M. Aleksunes(2), Tiandai Gao(2), Liam Berrigan(2)