Albena Kozekova

Vanderbilt University Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index756citations25works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(17), DNA Repair Mechanisms(16), Carcinogens and Genotoxicity Assessment(3), HIV/AIDS drug development and treatment(3), Bacterial Genetics and Biotechnology(2)

Publications25 total

Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB
Chemical Research in Toxicology·2014· 30 citedOpen Access
Replication Bypass of the <i>trans</i>-4-Hydroxynonenal-Derived (6<i>S</i>,8<i>R</i>,11<i>S</i>)-1,<i>N</i><sup>2</sup>-Deoxyguanosine DNA Adduct by the <i>Sulfolobus solfataricus</i> DNA Polymerase IV
Chemical Research in Toxicology·2012· 8 citedOpen Access
Structure of the duplex containing HNE derived (6S,8R,11S) gamma-HO-PdG when placed opposite dT
Biological Magnetic Resonance Bank·2012Open Access
Formation of a<i>N</i><sup>2</sup>-dG:<i>N</i><sup>2</sup>-dG Carbinolamine DNA Cross-link by the<i>trans</i>-4-Hydroxynonenal-Derived (6<i>S</i>,8<i>R</i>,11<i>S</i>) 1,<i>N</i><sup>2</sup>-dG Adduct
Journal of the American Chemical Society·2011· 13 citedOpen Access
Ternary complex of HNE Adduct modified DNA (5'-CXG-3' vs 13-mer) with Dpo4 and incoming dDGT
2011
Structure of the duplex containing HNE derived (6S,8R,11S) N2-dG cyclic hemiacetal when placed opposite dT
2011
γ-Hydroxy-1,<i>N</i><sup><i>2</i></sup>-propano-2′-deoxyguanosine DNA Adduct Conjugates the N-Terminal Amine of the KWKK Peptide via a Carbinolamine Linkage
Chemical Research in Toxicology·2011· 5 citedOpen Access
N2-dG:N2-dG interstrand cross-link induced by trans-4-hydroxynonenal
2011
Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,<i>N</i><sup>2</sup>-γ-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage,
Biochemistry·2010· 12 citedOpen Access
Comparison of the in Vitro Replication of the 7-(2-Oxoheptyl)-1,<i>N</i><sup>2</sup>-etheno-2′-deoxyguanosine and 1,<i>N</i><sup>2</sup>-Etheno-2′-deoxyguanosine Lesions by <i>Sulfolobus solfataricus</i> P2 DNA Polymerase IV (Dpo4)
Chemical Research in Toxicology·2010· 9 cited
DNA cross‐link induced by <i>trans</i>‐4‐hydroxynonenal
Environmental and Molecular Mutagenesis·2010· 46 citedOpen Access
Interstrand DNA Cross‐Linking 1, <i>N</i> 2‐Deoxyguanosine Adducts Derived from α,β‐Unsaturated Aldehydes: Structure–Function Relationships
2010· 2 cited
The C8-2′-Deoxyguanosine Adduct of 2-Amino-3-methylimidazo[1,2-<i>d</i>]naphthalene, a Carbocyclic Analogue of the Potent Mutagen 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline, Is a Block to Replication in Vitro
Chemical Research in Toxicology·2010· 10 cited
Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether
2010
Stereospecific Formation of the (<i>R</i>)-γ-Hydroxytrimethylene Interstrand <i>N</i><sup>2</sup>-dG:<i>N</i><sup>2</sup>-dG Cross-Link Arising from the γ-OH-1,<i>N</i><sup>2</sup>-Propano-2′-deoxyguanosine Adduct in the 5′-CpG-3′ DNA Sequence
Journal of the American Chemical Society·2009· 14 citedOpen Access
Translesion DNA Synthesis by Human DNA Polymerase η on Templates Containing a Pyrimidopurinone Deoxyguanosine Adduct, 3-(2′-Deoxy-β-<scp>d</scp>-<i>erythro</i>-pentofuranosyl)pyrimido-[1,2-<i>a</i>]purin-10(3<i>H</i>)-one
Biochemistry·2008· 18 citedOpen Access
Replication Bypass of the Acrolein-Mediated Deoxyguanine DNA-Peptide Cross-Links by DNA Polymerases of the DinB Family
Chemical Research in Toxicology·2008· 75 citedOpen Access
Rearrangement of the (6<i>S</i>,8<i>R</i>,11<i>S</i>) and (6<i>R</i>,8<i>S</i>,11<i>R</i>) Exocyclic 1,<i>N</i><sup>2</sup>-Deoxyguanosine Adducts of <i>trans</i>-4-Hydroxynonenal to <i>N</i><sup>2</sup>-Deoxyguanosine Cyclic Hemiacetal Adducts When Placed Complementary to Cytosine in Duplex DNA
Journal of the American Chemical Society·2008· 20 citedOpen Access
Interstrand DNA Cross-Links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources
Accounts of Chemical Research·2008· 185 citedOpen Access
The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts
Nucleic Acids Research·2008· 31 citedOpen Access
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Frequent Co-authors

Carmelo J. Rizzo(25), Michael P. Stone(19), Ivan D. Kozekov(15), Hai Huang(12), R. Stephen Lloyd(11), Hao Wang(9), Thomas M. Harris(7), Irina G. Minko(6), Plamen P. Christov(4), Hye‐Young Kim(3), Markus Voehler(3), Lawrence J. Marnett(3), F. Peter Guengerich(3), Amanda K. McCullough(3), Youngjin Cho(2), Youngjin Cho(2), Pamela Tamura(2), Jaison Jacob(2), R.S. Lloyd(2), Michael B. Harbut(1)