Carl E. Wagner

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index794citations72works3.02yr avg
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Research Topics

Retinoids in leukemia and cellular processes(38), Estrogen and related hormone effects(27), Antioxidant Activity and Oxidative Stress(14), Cutaneous lymphoproliferative disorders research(7), Crystallization and Solubility Studies(7)

Publications72 total

Modeling, synthesis and cell-based evaluation of pyridine-substituted analogs of CD3254 and fluorinated analogs of CBt-PMN as novel therapeutics
Bioorganic & Medicinal Chemistry·2025
Synergistic Activation of VDR-RXR Heterodimers by Vitamin D and Rexinoids in Human Kidney and Brain Cells
Cells·2024· 4 citedOpen Access
Rexinoids Induce Differential Gene Expression in Human Glioblastoma Cells and Protein–Protein Interactions in a Yeast Two-Hybrid System
ACS Chemical Neuroscience·2024· 5 cited
Development of Bexarotene Analogs for Treating Cutaneous T-Cell Lymphomas
Cells·2023· 10 citedOpen Access
Development of novel Bexarotene analogs for treating cutaneous T-cell lymphomas
Physiology·2023
Supplementary Data from Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention
2023Open Access
Data from Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention
2023Open Access
Supplementary Data from Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention
2023Open Access
Data from Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention
2023Open Access
An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene
International Journal of Molecular Sciences·2022· 8 citedOpen Access
Abstract 1118: The novel rexinoid V-125 reduces tumor growth in the MMTV-Neu model of breast cancer and the A/J model of lung cancer via immunomodulation
Cancer Research·2022
Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro
Frontiers in Immunology·2022· 6 citedOpen Access
The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer
Scientific Reports·2022· 17 citedOpen Access
Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene), (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)
SSRN Electronic Journal·2022Open Access
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)
International Journal of Molecular Sciences·2021· 9 citedOpen Access
The Rexinoid V-125 Reduces Tumor Growth in Preclinical Models of Breast and Lung Cancer
Research Square (Research Square)·2021Open Access
Bexarotene derivatives modify responses in acute myeloid leukemia
2021Open Access
Therapeutic Potential of Novel Rexinoids in Prevention and Treatment of Cancer and Alzheimer's Disease
The FASEB Journal·2021
Development of Novel Bexarotene Analogs for Treating Cutaneous T‐Cell Lymphomas
The FASEB Journal·2021
The Vitamin D Receptor and RXR Heteropartner Cooperate via Synergistic Activation to Control Target Gene Expression
The FASEB Journal·2021· 1 cited
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Frequent Co-authors

Peter W. Jurutka(32), Pamela A. Marshall(31), Arjan van der Vaart(10), Ichiro Kaneko(8), Joseph W. Ziller(7), Jaskaran S. Bhogal(7), Pritika H. Shahani(7), Kenneth J. Shea(6), Ning Ma(6), Sabeeha Reshi(6), Ana S. Leal(5), Sarah Carapellucci(5), Karen T. Liby(5), Zhela Sabir(5), Sanchita Mallick(5), Thomas L. Groy(4), Luis A. Montano(4), Chanh C. Huynh(4), Lisa M. Marcus(4), Geoffrey Gray(4)