James DeGregori

University of Colorado Anschutz Medical Campus — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

72h-index20.0kcitations375works12.32yr avg
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Research Topics

Cancer Genomics and Diagnostics(68), Acute Myeloid Leukemia Research(53), Epigenetics and DNA Methylation(47), Cancer-related Molecular Pathways(42), Cancer-related gene regulation(37)

Publications373 total

Hematopoietic stem cell aging promotes TET2 clonal hematopoiesis
2026Open Access
Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages
Cancer Discovery·2026Open Access
Cysteine protease cathepsin B promotes high population density-induced mutagenesis, driving genome evolution and competitive growth in response to the crowding stress
2025Open Access
Abstract A017: Influenza virus-induced expansion of dormant metastatic breast cancer in the lung alters tumor collagen program
Cancer Research·2025
Beyond clonal hematopoiesis of indeterminate potential: Understanding how the trisomy 21 context promotes TET2 mutations
Blood·2025Open Access
U2AF1S34F mutant HSPCs have a fitness advantage in aged and inflamed bone marrow
Blood·2025Open Access
3140 – A TÊTE-À-TÊTE ABOUT TRISOMY 21: ELUCIDATING HOW PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IMPACTS CLONAL HEMATOPOIESIS
Experimental Hematology·2025
The Role of Selection for Function in Aging and Chronic Diseases: A Novel Evolutionary Perspective
Aging Cell·2025· 2 citedOpen Access
Respiratory viral infections awaken metastatic breast cancer cells in lungs
Nature·2025· 29 citedOpen Access
Modelling the ageing dependence of cancer evolutionary trajectories
Nature reviews. Cancer·2025· 5 cited
Advancing cancer research via comparative oncology
Nature reviews. Cancer·2025· 6 citedOpen Access
The Nature and Nurture of Carcinogenesis
Cancer Discovery·2025
Abstract LB101: <i>Tet2</i> deficiency mitigates epigenetic aging in clonal hematopoiesis
Cancer Research·2025
Abstract 2777: Smoking, clonal evolution, and lung cancer risk
Cancer Research·2025
Abstract A014: <i>Tet2</i> deficiency mitigates epigenetic aging in clonal hematopoiesis
Cancer Research·2025
Aging and Cancer—Inextricably Linked Across the Lifespan
Aging Cell·2025· 5 citedOpen Access
Abstract IA007: Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs
Cancer Research·2024· 1 cited
<i>Title: In Vivo Clonal Tracing of Hematopoietic Stem and Progenitor Cells Reveals Increased Clonal Heterogeneity during Aging, Alongside Critical Changes in Selection Patterns</i>
Blood·2024Open Access
Selection Against U2AF1S34F Mutant HSPCs Is Rescued Via IL-1B Treatment
Blood·2024
Distinct Roles for mTOR- and CDK1-Dependent Translation in FLT3-Mutated AML Cell Survival
Blood·2024
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Frequent Co-authors

Joseph R. Nevins(13), Gustavo Leone(8), Angelo D’Alessandro(7), Laszlo Jakoi(6), Travis Nemkov(5), Craig T. Jordan(5), Daniel A. Pollyea(4), Vadym Zaberezhnyy(4), Aik Choon Tan(4), Kiyoshi Ohtani(3), Courtney L. Jones(3), Brett M. Stevens(3), Julie A. Reisz(3), Rachel Culp‐Hill(3), Shanshan Pei(3), Biniam Adane(3), D. Gale Johnson(3), Gustavo Leone(3), Eric M. Pietras(3), Mark A. Gregory(3)