Gavin O’Mahony

Institute of Medicinal Plant Development — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index1.2kcitations56works10.02yr avg
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Research Topics

Peroxisome Proliferator-Activated Receptors(7), Microbial Natural Products and Biosynthesis(5), Adipokines, Inflammation, and Metabolic Diseases(5), Orthopedic Surgery and Rehabilitation(5), Elbow and Forearm Trauma Treatment(5)

Publications53 total

Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism
JCI Insight·2024· 10 citedOpen Access
<i>N</i>-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–<i>Let-7</i> Interaction
ACS Medicinal Chemistry Letters·2023· 9 citedOpen Access
GalNAc-siRNA Mediated Knockdown of Ketohexokinase Versus Systemic, Small Molecule Inhibition of its Kinase Activity Exert Divergent Effects on Hepatic Metabolism in Mice on a HFD
2023Open Access
Correction to “Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction”
Journal of Medicinal Chemistry·2023Open Access
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction
Journal of Medicinal Chemistry·2022· 11 citedOpen Access
CCDC 2190057: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation
ACS Medicinal Chemistry Letters·2022· 14 citedOpen Access
A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes
STAR Protocols·2021· 8 citedOpen Access
Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes
Current Research in Pharmacology and Drug Discovery·2021· 5 citedOpen Access
Phosphorylated full‐length Tau interacts with 14‐3‐3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14‐3‐3 dimer
FEBS Journal·2020· 27 citedOpen Access
PPARγ and PPARα synergize to induce robust browning of white fat in vivo
Molecular Metabolism·2020· 84 citedOpen Access
<i>In vivo</i> liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
Theranostics·2019· 22 citedOpen Access
Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
PLoS ONE·2019· 4 citedOpen Access
1953-P: PPARγ Agonism and FGF-21 Synergize to Robustly Induce Browning of White Fat
Diabetes·2019
Abstract 297: <i>In vivo</i> Liposomal Drug Delivery Enriches Macrophage Targeting and Limits Liver and Kidney Drug Effects
Arteriosclerosis Thrombosis and Vascular Biology·2019
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection
Journal of Medicinal Chemistry·2018· 20 cited
Modulators of 14-3-3 Protein–Protein Interactions
Journal of Medicinal Chemistry·2017· 278 citedOpen Access
Adipose Tissue–Preserved Skin Graft: Applicability and Long-Term Results
Plastic & Reconstructive Surgery·2017· 10 cited
Stabilization of protein-protein interactions in drug discovery
Expert Opinion on Drug Discovery·2017· 165 citedOpen Access
Toward molecular imaging of the free fatty acid receptor 1
Acta Diabetologica·2017· 1 citedOpen Access
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Frequent Co-authors

Jérémie Boucher(7), Morten Grøtli(6), Paul J. Stevenson(6), Christian Ottmann(4), Matthew Harms(4), Victoria Osinski(4), Coleen A. McNamara(4), Francesco Bosica(4), Paul W. Armstrong(4), K. A. P. Edman(4), Anders Hogner(4), Andrew J. Wilson(3), Sebastian A. Andrei(3), Matthew W. D. Perry(3), Tobias Kroon(3), Peter Gennemark(3), Zhong-Qing Yuan(3), Eleonor Ehrman(3), Fabrizio Giordanetto(3), Ulla Karlsson(3)