Sieglinde De

Ghent University — Belgium

Medicine · Health Sciences

5h-index95citations9works2.52yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(7), SARS-CoV-2 and COVID-19 Research(6), Viral gastroenteritis research and epidemiology(2), Transgenic Plants and Applications(2), COVID-19 Clinical Research Studies(1)

Publications9 total

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base
Nature Communications·2025· 8 citedOpen Access
Modeling epithelial and endothelial cell tropism for SARS-CoV-2 through restricted transgenic hACE2 expression in mice
2025Open Access
Development of a General Purpose Targeted LC-MS Method for Accurate Quantification of the SARS-CoV-2 Spike Protein Expression
2025Open Access
P-2023. A ‘Variant-Proof’ Cocktail Of Two Heavy Chain-Only Antibodies Targets 3 Epitopes In The Spike Protein S1 And S2 Subunits And Broadly Neutralizes SARS-Cov-2 With Exceptional Potency
Open Forum Infectious Diseases·2025Open Access
Yeast-based production platform for potent and stable heavy chain-only antibodies
2024Open Access
Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted
EBioMedicine·2024· 7 citedOpen Access
Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike
2023· 6 citedOpen Access
An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models
Science Translational Medicine·2021· 66 citedOpen Access
Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents
2021· 8 citedOpen Access

Frequent Co-authors

Bert Schepens(9), Kenny Roose(7), Nico Callewaert(7), Xavier Saelens(7), Loes van Schie(6), Daria Fijałkowska(6), Koen Sedeyn(6), Rana Abdelnabi(6), Johan Neyts(6), Wim Nerinckx(5), Simon Devos(5), Chiara Lonigro(5), Jackeline Cecilia Zavala Marchan(5), Sandrine Vanmarcke(4), Hannah Eeckhaut(4), Dirk Jochmans(4), Han Remaut(4), Wannes Weyts(3), Iebe Rossey(3), Birgit Weynand(3)