Klaus‐Peter Knobeloch

University of Freiburg — Germany

Immunology and Microbiology · Life Sciences

48h-index9.4kcitations128works3.62yr avg
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Research Topics

interferon and immune responses(55), Ubiquitin and proteasome pathways(30), Neuroinflammation and Neurodegeneration Mechanisms(19), Cytokine Signaling Pathways and Interactions(18), Immunotherapy and Immune Responses(16)

Publications128 total

Inflammatory stimulus enhances synaptic material uptake by adult APP microglia in a microfluidic neuron–microglia co-culture model
Journal of Neuroinflammation·2026Open Access
Proximity labeling reveals non-catalytic interactions between DPP9 and ubiquitin signaling complexes
Cellular and Molecular Life Sciences·2026Open Access
Csf1r-mediated depletion of midbrain microglia prevents dopaminergic neuron loss during chronic colitis
2026Open Access
High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18
Angewandte Chemie·2025Open Access
High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18
Angewandte Chemie International Edition·2025Open Access
Enhanced ISGylation via USP18 Isopeptidase Inactivation Fails to Mitigate the Inflammatory or Functional Course of Coxsackievirus B3-Induced Myocarditis
Cellular Physiology and Biochemistry·2025· 1 citedOpen Access
Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture model
2025Open Access
Localised delivery of interleukin-13 from a PLGA microparticle embedded GelMA hydrogel improves functional and histopathological recovery in a mouse contusion spinal cord injury model
Bioactive Materials·2025· 1 citedOpen Access
Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis
Nature·2025· 13 citedOpen Access
Secreted ISG15 induced by Chlamydia trachomatis infection exerts immunomodulatory effects on IFN-γ defense and inflammation
PLoS Pathogens·2025· 2 citedOpen Access
USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
Advanced Science·2025· 3 citedOpen Access
High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-specific Protease USP18
2025· 2 citedOpen Access
A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding
2025· 3 citedOpen Access
ISG15 Drives Immune Pathology and Respiratory Failure during Systemic Lymphocytic Choriomeningitis Virus Infection
The Journal of Immunology·2024· 1 citedOpen Access
Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation
The Journal of Cell Biology·2024· 12 citedOpen Access
USP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10
2024· 6 citedOpen Access
USP8 Controls Proteostasis Pathways in B Cells and Multiple Myeloma
2024Open Access
In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases
Frontiers in Molecular Biosciences·2024· 12 citedOpen Access
ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection
Cardiovascular Research·2024· 16 citedOpen Access
Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation
2024· 1 citedOpen Access
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Frequent Co-authors

Marco Prinz(15), Ivan D. Horak(11), Anja Basters(7), Lars Ketscher(5), Katrin Kierdorf(4), G. Fritz(4), Lilliana Radoshevich(4), Francis Impens(4), Paul P. Geurink(3), Huib Ovaa(3), Jürgen Löhler(3), Jenni Raasch(3), Doron Merkler(3), E Rohde(3), Thomas Blank(3), Takahiro Masuda(3), Lukas Amann(3), Ori Staszewski(3), Josef Priller(3), Nicolas Zeller(3)