Mohammed A. I. Elbastawesy

Al-Azhar University — Egypt

Chemistry · Physical Sciences

10h-index304citations20works4.02yr avg
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Research Topics

Synthesis and biological activity(13), Cancer therapeutics and mechanisms(4), Synthesis and Biological Evaluation(4), Computational Drug Discovery Methods(3), Lung Cancer Treatments and Mutations(2)

Publications20 total

Design, synthesis, and biological evaluation of Benzimidazole–Aminopyrimidine hybrids as selective P38α MAPK inhibitors targeting Neuroinflammation in an AlCl3-induced rat model of Alzheimer's disease
Bioorganic Chemistry·2025· 1 cited
Microwave assisted synthesis, biological assessment and in-silico studies of some new 5,5′-(phenylmethylene)bisuracil and dihydropyrido[2,3-d:6,5-d']dipyrimidine derivatives as selective COX-2 inhibitors with potential anti-inflammatory activities
Journal of Molecular Structure·2025· 6 cited
Benzimidazole-Aminopyrimidine Hybrids as Potent and Selective p38α/β MAPK Inhibitors: Design, Synthesis, Molecular Modelling Study, in vitro Enzyme Inhibition Assays, and in vivo Efficacy in Alzheimer's Model
SSRN Electronic Journal·2025Open Access
New Pyrazole/Pyrimidine-Based Scaffolds as Inhibitors of Heat Shock Protein 90 Endowed with Apoptotic Anti-Breast Cancer Activity
Pharmaceuticals·2024· 9 citedOpen Access
Facile synthesis of 5-aminopyrazolo-quinolones
Monatshefte für Chemie - Chemical Monthly·2023
Facile synthesis of 5-aminopyrazolo-quinolones
Research Square (Research Square)·2023· 1 citedOpen Access
Design, Synthesis, Docking Study, and Antiproliferative Evaluation of Novel Schiff Base–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity
Molecules·2023· 21 citedOpen Access
Design, synthesis and antimicrobial activity of novel quinoline-2-one hybrids as promising DNA gyrase and topoisomerase IV inhibitors
Journal of Molecular Structure·2023· 15 cited
Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties
Frontiers in Chemistry·2022· 4 citedOpen Access
Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
Journal of Enzyme Inhibition and Medicinal Chemistry·2022· 19 citedOpen Access
New potent ciprofloxacin-uracil conjugates as DNA gyrase and topoisomerase IV inhibitors against methicillin-resistant Staphylococcus aureus
Bioorganic & Medicinal Chemistry·2022· 23 citedOpen Access
SYNTHESIS, BIOLOGICAL EVALUATION AND IN SILICO ADME PREDICTIONS OF SOME NEW COUMARIN-ACETAMIDE DERIVATIVES AS POTENT ANTI-INFLAMMATORY AGENTS
Bulletin of Pharmaceutical Sciences Assiut·2021Open Access
Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents
Molecules·2021· 23 citedOpen Access
New 4-thiazolidinone/quinoline-2-ones scaffold: Design, synthesis, docking studies and biological evaluation as potential urease inhibitors
Journal of Molecular Structure·2021· 25 cited
Synthesis, biological evaluation and in silico ADME predictions of some new coumarin-acetamide derivatives as potent anti-inflammatory agents
Bulletin of Pharmaceutical Sciences Assiut·2021Open Access
Quinolones as prospective drugs: Their syntheses and biological applications
Advances in heterocyclic chemistry·2020· 30 cited
Arylidenes of Quinolin-2-one scaffold as Erlotinib analogues with activities against leukemia through inhibition of EGFR TK/ STAT-3 pathways
Bioorganic Chemistry·2020· 26 cited
Identification and molecular modeling of new quinolin-2-one thiosemicarbazide scaffold with antimicrobial urease inhibitory activity
Molecular Diversity·2020· 27 cited
Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors
Bioorganic Chemistry·2019· 66 cited
Synthesis and biological evaluation of some new coumarin derivatives as potential antimicrobial, analgesic and anti-inflammatory agents
Der pharma chemica·2015· 8 cited

Frequent Co-authors

Mohamed Ramadan(8), Bahaa G. M. Youssif(8), Gamal El‐Din A. Abuo‐Rahma(8), Ashraf A. Aly(7), Yaseen A. M. M. Elshaier(7), Alan B. Brown(7), Stefan Bräse(4), Mostafa Abdelrahman(4), Mohamed Samir(3), Hesham A. M. Gomaa(3), Islam Zaki(3), Martha M. Morcoss(3), Nader E. Abo‐Dya(3), Alaa M. Hayallah(3), Essmat M. El‐Sheref(2), Mohamed Samir(2), Nehal M. Elsherbiny(2), Kamel Metwally(2), Riham Abouleisa(2), Tamer Mohamed(2)