Marina N. Asiedu

Aptinyx (United States) — United States

Medicine · Health Sciences

21h-index1.9kcitations35works0.02yr avg
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Research Topics

Pain Mechanisms and Treatments(29), Neuropeptides and Animal Physiology(10), Neuroscience and Neuropharmacology Research(8), Ion channel regulation and function(8), Nerve injury and regeneration(6)

Publications35 total

NYX-2925, A NOVEL, NON-OPIOID, SMALL-MOLECULE MODULATOR OF THE N-METHYL-d-ASPARTATE RECEPTOR (NMDAR), DEMONSTRATES POTENTIAL TO TREAT CHRONIC, SUPRASPINAL CENTRALIZED PAIN CONDITIONS
Medicine in Drug Discovery·2020· 4 citedOpen Access
The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC
Neurobiology of Pain·2019· 4 citedOpen Access
Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats
Neurobiology of Pain·2018· 39 citedOpen Access
Non-invasive dural stimulation in mice: A novel preclinical model of migraine
Cephalalgia·2018· 140 citedOpen Access
eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons
Frontiers in Cellular Neuroscience·2018· 51 citedOpen Access
Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice
Neuroscience·2017· 53 citedOpen Access
The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain
Journal of Neuroscience·2017· 138 citedOpen Access
(133) BDNF/TrkB signaling in the hyperalgesic priming model: temporal, sex and species differences
Journal of Pain·2017
(131) TLR4-dependent pain depends on different cell types in males and females
Journal of Pain·2017· 2 cited
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development
PLoS ONE·2017· 21 citedOpen Access
The potent, indirect adenosine monophosphate-activated protein kinase activator R419 attenuates mitogen-activated protein kinase signaling, inhibits nociceptor excitability, and reduces pain hypersensitivity in mice
PAIN Reports·2016· 14 citedOpen Access
(310) The mitochondrial complex one inhibitor R419 potently stimulates AMPK in dorsal root ganglion neurons and reduces incision-evoked pain in vivo
Journal of Pain·2016
Neuroligin 2 regulates spinal GABAergic plasticity in hyperalgesic priming, a model of the transition from acute to chronic pain
Pain·2016· 33 citedOpen Access
Targeting AMPK for the Alleviation of Pathological Pain
Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions·2016· 53 cited
The novel <scp>PAR</scp>2 ligand <scp>C</scp>391 blocks multiple <scp>PAR</scp>2 signalling pathways <i>in vitro</i> and <i>in vivo</i>
British Journal of Pharmacology·2015· 37 citedOpen Access
Meningeal norepinephrine produces headache behaviors in rats via actions both on dural afferents and fibroblasts
Cephalalgia·2015· 24 citedOpen Access
Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR2) through the Use of Lipid Tethering
PLoS ONE·2014· 17 citedOpen Access
A weak PAR2 partial agonist that can block PAR2 signaling initiated via protease and/or potent peptidomimetics (794.5)
The FASEB Journal·2014
Inhibition of Carbonic Anhydrase Augments GABAA Receptor-Mediated Analgesia via a Spinal Mechanism of Action
Journal of Pain·2014· 58 citedOpen Access
Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity
Molecular Pain·2014· 95 citedOpen Access
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Frequent Co-authors

Theodore J. Price(29), Gregory Dussor(18), Dipti V. Tillu(15), Ohannes K. Melemedjian(13), Galo L. Mejia(8), Jamie K. Moy(7), Josef Vágner(6), Salim Megat(5), Scott Boitano(5), Katherine A. Peebles(4), Jin Yan(4), Raul Sanoja(4), Michael D. Burton(4), Kai Kaila(4), Sourav Ghosh(4), Justin Hoffman(4), Nahum Sonenberg(3), C. Burgos-Vega(3), Andrea N. Flynn(3), Cara L. Sherwood(3)