Lee H. Chen

University of California, San Francisco — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.1kcitations80works13.82yr avg
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Research Topics

Epigenetics and DNA Methylation(29), Glioma Diagnosis and Treatment(27), RNA Research and Splicing(13), Neurogenesis and neuroplasticity mechanisms(13), Diet and metabolism studies(6)

Publications80 total

Abstract 3894: Three-dimensional whole tumor genomic analysis redefine intratumor heterogeneity of gliomas, with implications for early tumorigenesis
Cancer Research·2025
Tumour-wide RNA splicing aberrations generate actionable public neoantigens
Nature·2025· 43 citedOpen Access
Abstract 3907: Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types
Cancer Research·2024
Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma
Scientific Reports·2024· 12 citedOpen Access
Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma
2023· 5 citedOpen Access
Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens
2023· 7 citedOpen Access
Repurposing Clemastine to Target Glioblastoma Cell Stemness
Cancers·2023· 4 citedOpen Access
Abstract 3152: Targetable public neoantigens are generated by tumor-wide cancer-specific splicing events in gliomas
Cancer Research·2023
Data from Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
2023Open Access
Figure S1 from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
Figure S3 from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
Table S4 from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
Table S2 from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
Supplementary Table 2 from Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
2023Open Access
Supplementary Table 1 from Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
2023Open Access
Figure S3 from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
Figure S2 from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
Data from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
Supplementary Table 3 from Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
2023Open Access
Data from CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP
2023Open Access
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Frequent Co-authors

Christopher J. Pirozzi(35), Matthew S. Waitkus(33), Bill H. Diplas(29), Paula K. Greer(29), Yiping He(29), Darell D. Bigner(28), Roger E. McLendon(27), Casey J. Moure(27), Hai Yan(25), Landon J. Hansen(23), Huishan Zhu(21), Rui Yang(21), Austin B. Carpenter(20), Ivan Spasojević(16), Hai Yan(13), Yiping He(12), Heng Liu(10), Zhaohui Wang(9), Rui Yang(7), Nicholas Stevers(6)