Aude Chefdeville

Charles River Laboratories (Netherlands) — Netherlands

Medicine · Health Sciences

13h-index593citations23works0.02yr avg
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Research Topics

Pain Mechanisms and Treatments(11), Axon Guidance and Neuronal Signaling(9), Autoimmune Neurological Disorders and Treatments(6), Neuroscience and Neuropharmacology Research(5), Neurofibromatosis and Schwannoma Cases(4)

Publications23 total

P31-24 Pharmacological validation of integrated nerve conduction velocity assays, functional observational battery and videotracking in the rat using peripheral nerve toxicants
Toxicology Letters·2025
A peptidomimetic modulator of the Ca <sub>V</sub> 2.2 N-type calcium channel for chronic pain
Proceedings of the National Academy of Sciences·2023· 31 citedOpen Access
A rationally designed peptidomimetic modulator of CaV2.2 (N-type) voltage-gated calcium channels for chronic pain
2022Open Access
Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents
Science Translational Medicine·2021· 52 citedOpen Access
Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain
Pain·2021· 15 citedOpen Access
Druggability of CRMP2 for Neurodegenerative Diseases
ACS Chemical Neuroscience·2020· 26 cited
Studies on CRMP2 SUMOylation–deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain
Pain·2020· 35 citedOpen Access
Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain
2020· 3 citedOpen Access
Validating indicators of CNS disorders in a swine model of neurological disease
PLoS ONE·2020· 6 citedOpen Access
Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1
Pain·2019· 21 citedOpen Access
Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions
Molecular Neurobiology·2019· 83 citedOpen Access
Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis
Acta Neuropathologica Communications·2019· 96 citedOpen Access
Targeting the CaVα–CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy
Pain·2019· 43 citedOpen Access
Validating indicators of CNS disorders in a swine model of neurological disease
2019· 1 citedOpen Access
Sex-dependent differences in pain and sleep in a porcine model of Neurofibromatosis type 1
2018· 3 citedOpen Access
Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission
Molecular Neurobiology·2018· 49 citedOpen Access
Targeting the CaVα-β interaction yields a selective antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy
2018Open Access
Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury–associated peripheral sensory neuropathy via block of N- and T-type calcium channels
Pain·2018· 60 cited
NMDAR Encephalitis, a model of synaptopathy
theses.fr (ABES)·2017Open Access
L'encéphalite à auto-anticorps anti-NMDAR, un modèle de synaptopathie
HAL (Le Centre pour la Communication Scientifique Directe)·2017Open Access
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Frequent Co-authors

Rajesh Khanna(16), Aubin Moutal(13), Shreya S. Bellampalli(7), Jie Yu(7), Jill M. Weimer(6), Song Cai(6), Lindsey A. Chew(6), Samantha Perez‐Miller(6), Katherine A. White(5), Cynthia L. Madura(5), May Khanna(5), Kimberly Gómez(5), Yuan Zhou(5), Jérôme Honnorat(4), Angie Dorame(4), Shizhen Luo(4), Marcel Pátek(4), Lisa Boinon(4), Vicki J. Swier(4), Dawn E. Quelle(4)