Andrew Cooke

Exscien (United States) — United States

Medicine · Health Sciences

14h-index916citations32works0.02yr avg
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Research Topics

Cancer Mechanisms and Therapy(9), Nuclear Receptors and Signaling(6), Growth Hormone and Insulin-like Growth Factors(4), Enzyme function and inhibition(4), Estrogen and related hormone effects(3)

Publications32 total

832P Characterisation of EXS73565: A potent and selective MALT1 inhibitor with low drug-drug interaction risk and potential in lymphoma
Annals of Oncology·2023· 2 citedOpen Access
Supplementary Figures 1-3 from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Supplementary Figure Legends from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Supplementary Tables 1-2 from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Supplementary Figure Legends from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Data from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Data from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Supplementary Tables 1-2 from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Supplementary Figures 1-3 from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
2023Open Access
Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics
Bioorganic & Medicinal Chemistry Letters·2013· 26 citedOpen Access
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1
Bioorganic & Medicinal Chemistry Letters·2013· 20 citedOpen Access
AUGMENTED REALITY IN DESIGN DEVELOPMENT: REPRESENTATION TO REFINEMENT
ICERI2013 Proceedings·2013
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 20 citedOpen Access
ChemInform Abstract: Microwave‐Promoted Tandem Reactions for the Synthesis of Bicyclic γ‐Lactams.
ChemInform·2011
Microwave-promoted tandem reactions for the synthesis of bicyclic γ-lactams
Tetrahedron Letters·2011· 14 cited
Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2
Bioorganic & Medicinal Chemistry Letters·2011· 22 citedOpen Access
ChemInform Abstract: A Three‐Step Tandem Process for the Synthesis of Bicyclic γ‐Lactams.
ChemInform·2010
A three-step tandem process for the synthesis of bicyclic γ-lactams
Organic & Biomolecular Chemistry·2010· 34 cited
Discovery of OSI-906: A Selective and Orally Efficacious Dual Inhibitor of the IGF-1 Receptor and Insulin Receptor
Future Medicinal Chemistry·2009· 307 citedOpen Access
SAR, Pharmacokinetics, Safety, and Efficacy of Glucokinase Activating 2-(4-Sulfonylphenyl)-<i>N</i>-thiazol-2-ylacetamides: Discovery of PSN-GK1
Journal of Medicinal Chemistry·2008· 54 citedOpen Access
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Frequent Co-authors

Mark Bittner(15), Neil W. Gibson(14), Andrew P. Crew(14), Lee D. Arnold(12), Jennifer Kahler(11), Shannon L. Winski(11), Mary C. Srebernak(11), Arlindo L. Castelhano(11), Mark J. Mulvihill(10), Paul Briner(10), An‐Hu Li(10), Andrew J. Garton(9), Maryland Franklin(9), Graham M. Wynne(9), Linda Castaldo(9), April Franks(9), John F. Keily(9), Chris Hidden(9), Carrie Pirrit(9), Bojana Vulevic(9)