Debra L. Silver

Sunnybrook Health Science Centre — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index4.8kcitations113works3.92yr avg
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Research Topics

RNA Research and Splicing(41), RNA modifications and cancer(22), Neurogenesis and neuroplasticity mechanisms(16), Cytokine Signaling Pathways and Interactions(12), Genomics and Chromatin Dynamics(10)

Publications113 total

Glucose biomarkers and antidepressant response: A scoping review of interventions targeting major depressive disorder and metabolic dysfunction
Journal of Affective Disorders·2025
Shaping the Neocortex: Radial Glia and Astrocytes in Development and Evolution
Journal of Neuroscience·2025· 2 cited
Dissecting mammalian cortical circuit development at single-cell resolution using inducible barcoded rabies virus
2025Open Access
Impaired cortical development and translational control in a missense mouse model of <i>DDX3X</i> syndrome
Disease Models & Mechanisms·2025Open Access
Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans
2025· 1 citedOpen Access
Subcellular transcriptome of radial glia reveals compartmentalized control of cortical development
2025· 1 citedOpen Access
Species-specific chromatin architecture and neurogenesis mediated by a human enhancer
2025Open Access
A human-specific enhancer fine-tunes radial glia potency and corticogenesis
Nature·2025· 14 cited
306. Association Between Glycemic Control and Accelerated RTMS Efficacy in Treatment-Resistant Depression
Biological Psychiatry·2025
mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis
PLoS Biology·2025· 10 citedOpen Access
Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations
PLoS Genetics·2025· 4 citedOpen Access
Genomic basis of human-specific brain features
Elsevier eBooks·2025
Interleaved iTBS-fMRI for assessing neural circuit engagement in ultra treatment-resistant depression
Brain stimulation·2025Open Access
How our brains are built: emerging approaches to understand human-specific features
Current Opinion in Genetics & Development·2024· 5 cited
The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton
Cell Reports·2024· 15 citedOpen Access
mRNA stability fine tunes gene expression in the developing cortex to control neurogenesis
2024
A human-specific enhancer fine-tunes radial glia potency and corticogenesis
2024· 10 citedOpen Access
A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X
Molecular Systems Biology·2024· 9 citedOpen Access
What approaches are needed to understand human development and disease?
Developmental Cell·2023
Posttranscriptional Control of Brain Development
2023
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Frequent Co-authors

Louis‐Jan Pilaz(12), John J. McMahon(8), Fernando C. Alsina(7), William J. Pavan(5), Hanqian Mao(5), Camila Manso Musso(5), Denise J. Montell(4), Ashley L. Lennox(4), Emily E. Miller(4), Federica Mosti(4), Scott H. Soderling(3), Çağla Eroğlu(3), Mariah L. Hoye(3), James R. Sellers(3), Ling Hou(3), Jeremy P. Rouanet(2), Gregory A. Wray(2), Suneel Apte(2), Charles J. Sheehan(2), Stephen N. Floor(2)