Orla M. Conneely

Baylor College of Medicine — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

64h-index15.2kcitations140works0.02yr avg
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Research Topics

Estrogen and related hormone effects(57), Nuclear Receptors and Signaling(38), Infant Nutrition and Health(22), RNA Interference and Gene Delivery(18), Reproductive System and Pregnancy(16)

Publications140 total

Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors
Scientific Reports·2020· 28 citedOpen Access
Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia
Leukemia·2018· 31 citedOpen Access
Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells
PLoS ONE·2018· 13 citedOpen Access
NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling
Blood·2018· 73 citedOpen Access
Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer
Oncotarget·2017· 60 citedOpen Access
Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells
PLoS ONE·2016· 42 citedOpen Access
Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus
eNeuro·2015· 21 citedOpen Access
The Orphan Nuclear Receptor Nur77 Is a Determinant of Myofiber Size and Muscle Mass in Mice
Molecular and Cellular Biology·2015· 48 citedOpen Access
REGULATOR OF MUSCLE MASS POINT: IGF IS THE MAJOR PHYSIOLOGICAL
2015
Abstract LB-83: Transcriptional mechanisms of NR4A orphan nuclear receptor tumor suppression in AML
Cancer Research·2014
Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content
PLoS ONE·2014· 19 citedOpen Access
Research Resource: Progesterone Receptor Targetome Underlying Mammary Gland Branching Morphogenesis
Molecular Endocrinology·2013· 43 citedOpen Access
A Translational Approach to Validate in Vivo Anti-tumor Effects of Chloroquine on Breast Cancer Risk
2013
Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice
Journal of Lipid Research·2013· 56 citedOpen Access
HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML
Leukemia·2012· 86 citedOpen Access
Genome-wide profiling reveals transcriptional repression of MYC as a core component of NR4A tumor suppression in acute myeloid leukemia
Oncogenesis·2012· 55 citedOpen Access
Abstract 3387: Deletion of NR4A orphan nuclear receptors in adult mice leads to development of acute myeloid leukemia due to disrupted HSC homeostasis
Cancer Research·2011
Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice
Blood·2011· 96 citedOpen Access
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
Nature Cell Biology·2010· 96 cited
Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis
Circulation Research·2010· 87 citedOpen Access
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Frequent Co-authors

Bert W. O’Malley(19), John P. Lydon(12), Francesco J. DeMayo(8), Biserka Mulac‐Jeričević(6), Pauline P. Ward(5), William T. Schrader(4), Tiia Pönniö(4), Odila Saucedo‐Cárdenas(3), Ronan F. Power(3), David O. Toft(3), Beth Lynn Maxwell(3), Ming‐Jer Tsai(3), Todd A. Tibbetts(3), Evelyn P. Murphy(3), Shaila K. Mani(2), Weidong Le(2), Marten P. Smidt(2), J. Peter H. Burbach(2), Shannon E. Mullican(2), Geoffrey L. Greene(2)