Paul J. Maddon

Healthcentric Advisors — United States

Immunology and Microbiology · Life Sciences

40h-index14.8kcitations67works0.02yr avg
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Research Topics

HIV Research and Treatment(50), Immune Cell Function and Interaction(33), HIV/AIDS drug development and treatment(26), Monoclonal and Polyclonal Antibodies Research(16), T-cell and B-cell Immunology(11)

Publications67 total

PRO 140, a monoclonal antibody targeting CCR5, as a long-acting, single-agent maintenance therapy for HIV-1 infection
HIV Clinical Trials·2018· 49 cited
Protection Against Clostridium difficile Infection With Broadly Neutralizing Antitoxin Monoclonal Antibodies
The Journal of Infectious Diseases·2012· 82 citedOpen Access
Novel Small-Molecule Inhibitors of Hepatitis C Virus Entry Block Viral Spread and Promote Viral Clearance in Cell Culture
PLoS ONE·2012· 13 citedOpen Access
774 SUBSTITUTION OF A CONSERVED AMINO ACID IN THE TRANSMEMBRANE DOMAIN OF E2 CONFERS RESISTANCE TO A NOVEL SMALL-MOLECULE INHIBITOR OF HCV ENTRY
Journal of Hepatology·2011Open Access
Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults
Antimicrobial Agents and Chemotherapy·2010· 90 citedOpen Access
Anti–HIV‐1 Activity of Weekly or Biweekly Treatment with Subcutaneous PRO 140, a CCR5 Monoclonal Antibody
The Journal of Infectious Diseases·2010· 96 citedOpen Access
112 DISCOVERY OF POTENT AND SELECTIVE INHIBITORS OF HEPATITIS C VIRUS (HCV) ENTRY WITH DISTINCT MECHANISMS OF ACTION
Journal of Hepatology·2010Open Access
Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1
Vaccine·2009· 61 citedOpen Access
7 PRECLINICAL CHARACTERIZATION OF PRO 206, AN ORALLY ACTIVE SMALL-MOLECULE HEPATITIS C (HCV) ENTRY INHIBITOR
Journal of Hepatology·2009Open Access
Antiviral Activity of Single‐Dose PRO 140, a CCR5 Monoclonal Antibody, in HIV‐Infected Adults
The Journal of Infectious Diseases·2008· 112 citedOpen Access
A Novel Alphavirus Vaccine Encoding Prostate-Specific Membrane Antigen Elicits Potent Cellular and Humoral Immune Responses
Clinical Cancer Research·2007· 70 cited
Purified, Proteolytically Mature HIV Type 1 SOSIP gp140 Envelope Trimers
AIDS Research and Human Retroviruses·2007· 21 cited
A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120
Virology·2006· 99 cited
Potent Antiviral Synergy between Monoclonal Antibody and Small-Molecule CCR5 Inhibitors of Human Immunodeficiency Virus Type 1
Antimicrobial Agents and Chemotherapy·2006· 91 citedOpen Access
L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles
Journal of General Virology·2006· 13 cited
Construction and Characterization of Soluble, Cleaved, and Stabilized Trimeric Env Proteins Based on HIV Type 1 Env Subtype A
AIDS Research and Human Retroviruses·2006· 23 cited
Potent Antitumor Activity of an Auristatin-Conjugated, Fully Human Monoclonal Antibody to Prostate-Specific Membrane Antigen
Clinical Cancer Research·2006· 134 cited
Evaluating the Immunogenicity of a Disulfide-Stabilized, Cleaved, Trimeric Form of the Envelope Glycoprotein Complex of Human Immunodeficiency Virus Type 1
Journal of Virology·2005· 119 citedOpen Access
Molecular targeting of prostate cancer with cytotoxins and radioisotopes linked to fully human monoclonal antibodies against prostate-specific membrane antigen
Journal of Clinical Oncology·2005
Treatment of Advanced Human Immunodeficiency Virus Type 1 Disease with the Viral Entry Inhibitor PRO 542
Antimicrobial Agents and Chemotherapy·2004· 123 cited
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Frequent Co-authors

William C. Olson(27), John P. Moore(14), Graham P. Allaway(10), Richard Axel(10), Kirsten Nagashima(9), J. Steven McDougal(9), Tatjana Dragic(6), Gerald P. Donovan(6), Michael Franti(6), Angus Dalgleish(5), Alexandra Trkola(5), Jeffrey M. Jacobson(5), Richard A. Koup(4), Paul R. Clapham(4), Robin A. Weiss(4), James Μ. Binley(4), Dan R. Littman(4), Maurice Godfrey(4), Leonard Chess(4), Rogier W. Sanders(4)