Livio Brasili

University of Modena and Reggio Emilia — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index1.5kcitations193works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(64), Pharmacological Receptor Mechanisms and Effects(26), Neurotransmitter Receptor Influence on Behavior(23), Synthesis and Biological Evaluation(21), Chemical Synthesis and Analysis(20)

Publications193 total

BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting
International Journal of Molecular Sciences·2023· 5 citedOpen Access
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands
Results in Chemistry·2022· 1 citedOpen Access
CCDC 982474: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Identification of a Potent and Selective 5-HT<sub>1A</sub> Receptor Agonist with <i>In Vitro</i> and <i>In Vivo</i> Antinociceptive Activity
ACS Chemical Neuroscience·2020· 15 citedOpen Access
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs)
Bioorganic Chemistry·2020· 18 citedOpen Access
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents
ACS Medicinal Chemistry Letters·2020· 13 citedOpen Access
Spiroxatrine derivatives towards 5-HT1A receptor selectivity
Pharmacological Reports·2020· 1 citedOpen Access
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity
European Journal of Medicinal Chemistry·2019· 23 citedOpen Access
Effect of the rigidification of propranolol, a mixed <i>β</i>-adrenoceptor and 5-HT<sub>1A</sub>R antagonist.
PubMed·2019
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer
IRIS UNIMORE (University of Modena and Reggio Emilia)·2019
IDENTIFICATION OF POTENT 1,3-DIOXOLANE-BASED 5-HT1A RECEPTOR AGONISTS FOR THE TREATMENTS OF CNS DISORDERS AND PAIN
IRIS UNIMORE (University of Modena and Reggio Emilia)·2019
Synthesis and Biological Evaluation of 1,3-dioxolane-based 5-HT<sub>1A</sub>Receptor Agonists for CNS Disorders and Neuropathic Pain
Future Medicinal Chemistry·2018· 12 cited
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-relatedabuse
2018
Structure–Activity Relationships within a Series of σ<sub>1</sub> and σ<sub>2</sub> Receptor Ligands: Identification of a σ<sub>2</sub> Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma
ChemMedChem·2017· 8 citedOpen Access
CCDC 1055779: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1055778: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT<sub>1A</sub> ligands
Journal of Enzyme Inhibition and Medicinal Chemistry·2017· 11 citedOpen Access
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists
European Journal of Medicinal Chemistry·2016· 32 citedOpen Access
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides
Archives of Pharmacal Research·2016· 3 citedOpen Access
ChemInform Abstract: Synthesis of Heteroaryl ortho‐Phenoxyethylamines via Suzuki Cross‐Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry.
ChemInform·2016
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Frequent Co-authors

Silvia Franchini(20), Claudia Sorbi(16), Wilma Quaglia(15), Maria Pigini(15), Paola Fossa(11), Gabriella Marucci(11), Elena Cichero(10), Carlo Melchiorre(10), Annalisa Tait(10), Pascal Bousquet(8), Antonio Cilia(8), Piero Angeli(8), Maddalena Giannella(7), Monique Dontenwill(7), Alessandro Piergentili(7), Dario Giardinà(7), Michela Buccioni(7), Umberto Maria Battisti(7), Adolfo Prandi(6), Lorenza Pirona(6)