Michael C. Gundry

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.8kcitations41works1.62yr avg
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Research Topics

CRISPR and Genetic Engineering(17), Acute Myeloid Leukemia Research(14), Epigenetics and DNA Methylation(9), CAR-T cell therapy research(8), Protein Degradation and Inhibitors(7)

Publications41 total

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias
Blood·2025· 3 citedOpen Access
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias
2024· 2 citedOpen Access
Targeted Protein Degradation Reveals a Repressive Role of Mecom at the <i>CEBPA</i> Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia
Blood·2024Open Access
Mutant NPM1 marginally impacts ribosome footprint in acute myeloid leukemia cells
eJHaem·2024· 2 citedOpen Access
Abstract 1687: Targeted degradation of MECOM in high-risk acute myeloid leukemia reveals a novel repressive function that is amenable to therapeutic small-molecule rewiring
Cancer Research·2024· 1 cited
DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
Nature Cell Biology·2023· 26 citedOpen Access
Hacking hematopoiesis – emerging tools for examining variant effects
Disease Models & Mechanisms·2023· 2 citedOpen Access
Modeling <i>IKZF1</i> lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities
Blood Advances·2021· 10 citedOpen Access
Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage
Science Advances·2021· 18 citedOpen Access
Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells
Blood Advances·2020· 33 citedOpen Access
Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion
Cell stem cell·2020· 32 citedOpen Access
Modeling <i>IKZF1</i> lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities
2020Open Access
It’s All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice
Cancer Cell·2020· 26 citedOpen Access
Topologically Dependent Abundance of Spontaneous DNA Damage in Single Human Cells
2019· 2 citedOpen Access
New insights into the biology of acute myeloid leukemia with mutated NPM1
International Journal of Hematology·2019· 43 citedOpen Access
Precise Modeling of IKZF1 Alterations in Human B-Cell Acute Lymphoblastic Leukemia Cell Lines Reveals Distinct Chemosensitivity, Homing, and Engraftment Properties
Blood·2018· 2 cited
Mutant NPM1 Maintains the Leukemic State through HOX Expression
Cancer Cell·2018· 306 cited
Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
Journal of Visualized Experiments·2018· 17 citedOpen Access
Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
Journal of Visualized Experiments·2018· 26 citedOpen Access
Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity
eLife·2018· 64 citedOpen Access
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Frequent Co-authors

Margaret A. Goodell(26), Lorenzo Brunetti(24), Anna Guzman(10), Yung‐Hsin Huang(6), Mira Jeong(6), Yong Lei(5), Xiaotian Zhang(5), Jianzhong Su(5), Wei Li(5), Jaime M. Reyes(5), Vijay G. Sankaran(5), Brunangelo Falini(4), Rachel E. Rau(4), Travis Fleming(4), Mateusz Antoszewski(4), Richard A. Voit(4), Raghav Ramabadran(3), Ilaria Gionfriddo(3), Federica Mezzasoma(3), Francesca Milano(3)