Thomas E. Prisinzano

University of Kentucky — United States

Neuroscience · Life Sciences

51h-index7.0kcitations287works1.42yr avg
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Research Topics

Neuropeptides and Animal Physiology(117), Receptor Mechanisms and Signaling(95), Neurotransmitter Receptor Influence on Behavior(57), Pharmacological Receptor Mechanisms and Effects(48), Pain Mechanisms and Treatments(39)

Publications287 total

Development and Application of an LC–MS Method for the Pharmacokinetics and Pharmacodynamics of Oral Therapeutic Efficacy of Nalfurafine
Basic & Clinical Pharmacology & Toxicology·2025
Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol
Neuropsychopharmacology·2025· 2 citedOpen Access
Stuffed Epimerase Domains of Pyochelin Biosynthesis are Defunct Methyltransferases
Biochemistry·2025
N-(3-Hydroxyphenyl)-3,8-diazabicyclooctanes as opioid receptors probes. 1. Investigation of the phenolic hydroxyl group
European Journal of Medicinal Chemistry·2025
Searching for Synthetic Opioid Rescue Agents. 2: Identification of an Ultra-Potent Synthetic Opioid Rescue Agent
Journal of Medicinal Chemistry·2025· 1 cited
Preclinical Pharmacokinetic Evaluation of Mithramycin and Mithramycin SA Tryptophan-Conjugated Analog
Pharmaceutics·2025Open Access
Transformation of a Potent C9-Substituted Phenylmorphan into MOR Partial Agonists with Improvement of Metabolic Stability: An In Vitro, In Vivo, and In Silico Study
ACS Chemical Neuroscience·2025
Winners of the 2024 Tu Youyou Award
Molecules·2025Open Access
Abstract 4360: Development of a novel mithramycin analogue with improved pharmacokinetics and therapeutic window for targeted inhibition of EWS-FLI1 in Ewing sarcoma
Cancer Research·2025· 1 cited
Arnica Ethanolic Extract Relieves Post-Operative Pain
Journal of Pain·2025
Ligand Recognition and G Protein Signaling Diversification in the Kappa Opioid Receptor (Abstract ID: 162058)
Journal of Pharmacology and Experimental Therapeutics·2025
Novel Compounds EO-139 and YZ-166 as Potential Countermeasures for Reversing Fentanyl-Induced Antinociception, Motor Incapacitation and Respiratory Depression
Drug and Alcohol Dependence·2025
Effects of Biased Analogues of the Kappa Opioid Receptor Agonist, U50,488, in Preclinical Models of Pain and Side Effects
Molecules·2025· 7 citedOpen Access
Nalmefene enhances the remyelinating ability of nalfurafine when administered therapeutically at very low doses during experimental autoimmune encephalomyelitis
Clinical & Translational Immunology·2025Open Access
Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression
Environmental Toxicology and Pharmacology·2024· 6 citedOpen Access
ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION
Drug and Alcohol Dependence·2024
XYLAZINE REDUCES INTRAVENOUS FENTANYL CONSUMPTION BUT DOES NOT IMPAIR LEVER DISCRIMINATION IN MALE AND FEMALE RATS
Drug and Alcohol Dependence·2024
Topical Use of Arnica Ethanolic Extract Reduces Post-operative Pain via the Nrf2 Signaling Pathway
Current Developments in Nutrition·2024Open Access
Nalfurafine promotes myelination <scp><i>in vitro</i></scp> and facilitates recovery from cuprizone + rapamycin‐induced demyelination in mice
Glia·2024· 5 citedOpen Access
Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression
Journal of Medicinal Chemistry·2024· 7 citedOpen Access
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Frequent Co-authors

Kevin Tidgewell(16), Richard B. Rothman(15), Wayne W. Harding(12), Christina M. Dersch(8), Laura Bohn(7), Matthew Schmidt(7), Bronwyn M. Kivell(6), John S. Partilla(5), Eduardo R. Butelman(5), Jeffrey Aubé(4), Amy Ewald(4), Mary Jeanne Kreek(4), Anthony Lozama(4), Chad E. Groer(3), Michael H. Baumann(3), Kevin J. Frankowski(3), Amy Hauck Newman(3), Mark S. Schmidt(3), Daryl J. Murry(3), Hernán A. Navarro(3)