Aicha Saadane

University of California, Irvine — United States

Medicine · Health Sciences

19h-index1.2kcitations44works1.32yr avg
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Research Topics

Retinal Diseases and Treatments(19), Cholesterol and Lipid Metabolism(11), Retinal Development and Disorders(8), Systemic Lupus Erythematosus Research(5), Cystic Fibrosis Research Advances(4)

Publications43 total

Theophylline Inhibits Capillary Degeneration in Early Diabetic Retinopathy
Investigative Ophthalmology & Visual Science·2026Open Access
The retinol-binding protein receptor STRA6 and melanin cooperatively sustain retinoid signaling and outer blood-retinal barrier integrity
Journal of Biological Chemistry·2025Open Access
Structural bias in vitamin A metabolism: Why α-retinoids miss the eye
Journal of Biological Chemistry·2025Open Access
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine
Journal of Lipid Research·2025· 5 citedOpen Access
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition
Proceedings of the National Academy of Sciences·2023· 16 citedOpen Access
CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice
Diabetologia·2023· 39 citedOpen Access
ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes
Diabetologia·2022· 18 citedOpen Access
Low-Dose Anti-HIV Drug Efavirenz Mitigates Retinal Vascular Lesions in a Mouse Model of Alzheimer’s Disease
Frontiers in Pharmacology·2022· 12 citedOpen Access
Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy
Investigative Ophthalmology & Visual Science·2021· 31 citedOpen Access
Table of Contents
American Journal Of Pathology·2021Open Access
Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy
American Journal Of Pathology·2021· 18 citedOpen Access
Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice
PLoS ONE·2021· 13 citedOpen Access
Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy
PLoS ONE·2020· 81 citedOpen Access
Studies of ApoD−/− and ApoD−/−ApoE−/− mice uncover the APOD significance for retinal metabolism, function, and status of chorioretinal blood vessels
Cellular and Molecular Life Sciences·2020· 18 citedOpen Access
The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina
Biomolecules·2019· 12 citedOpen Access
Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy
Diabetologia·2019· 67 citedOpen Access
Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy
Investigative Ophthalmology & Visual Science·2019· 57 citedOpen Access
Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal
American Journal Of Pathology·2018· 41 citedOpen Access
Mechanisms that minimize retinal impact of apolipoprotein E absence
Journal of Lipid Research·2018· 27 citedOpen Access
N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity
Frontiers in Pharmacology·2018· 20 citedOpen Access
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Frequent Co-authors

Irina A. Pikuleva(17), Natalia Mast(14), Timothy S. Kern(13), Emma M. Lessieur(9), Yunpeng Du(8), Haitao Liu(6), Jianying Kiser(6), Casey D. Charvet(6), Nicole El‐Darzi(6), Melvin Berger(5), Wenchao Zheng(5), Krzysztof Palczewski(3), Saida Omarova(3), Susan S. Huang(3), Neal S. Peachey(3), Tung Van Dao(3), Alexey M. Petrov(3), A. A. Astaf’ev(3), Bernard Lardeux(3), F Bleiberg‐Daniel(3)