Patrick J. Paddison

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa — South Africa

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index8.9kcitations161works1.92yr avg
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Research Topics

CRISPR and Genetic Engineering(35), Microtubule and mitosis dynamics(34), RNA Research and Splicing(24), Glioma Diagnosis and Treatment(21), Ubiquitin and proteasome pathways(20)

Publications160 total

N6-methyladenosine regulation of mRNA translation is essential for early human erythropoiesis
2025Open Access
STEM-26. COMPREHENSIVE FUNCTIONAL GENOMIC SCREENS REVEAL HUMAN TRANSCRIPTION FACTORS REQUIRED TO MAINTAIN GLIOBLASTOMA OLIGODENDROCYTE PROGENITOR CELL-LIKE IDENTITY
Neuro-Oncology·2025Open Access
CSIG-34. MAP KINASE-INDUCED KINETOCHORE STRESS IN GLIOBLASTOMA
Neuro-Oncology·2025Open Access
Characterization of quiescent subpopulations and proliferative compartments in glioblastoma
2025Open Access
Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures
2025Open Access
Abstract P3-04-21: Optimization of lentiviral transduction of a triple-negative breast cancer patient-derived xenograft organoid for modeling tumor cell quiescence and associated treatment resistance
Clinical Cancer Research·2025
KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma
Nature Communications·2025· 3 citedOpen Access
In vivo functional screens reveal <i>KEAP1</i> loss as a driver of chemoresistance in small cell lung cancer
Science Advances·2025· 2 citedOpen Access
Abstract B043: BDNF-TrkB.T1 signaling increases neutrophil recruitment and epithelial-to- mesenchymal transition in gliomas
Cancer Research·2024
Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomics
2024· 7 citedOpen Access
<i>FBXO42</i> activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers
NAR Cancer·2024· 7 citedOpen Access
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype
Genes & Development·2024· 4 citedOpen Access
MODL-41. LOSS OF DISTAL CHROMOSOME 6Q AND ASSOCIATED <i>PDE10A</i> INDUCES AN AGGRESSIVE GLIOMA PHENOTYPE BY FACILITATING PRONEURAL TO MESENCHYMAL TRANSITION
Neuro-Oncology·2023Open Access
STEM-24. WDR5 REPRESENTS A THERAPEUTICALLY EXPLOITABLE TARGET FOR CANCER STEM CELLS IN GLIOBLASTOMA
Neuro-Oncology·2023Open Access
CCRG-02. DEVELOPMENTALLY PARTITIONED PROLIFERATIVE COMPARTMENTS IN GLIOBLASTOMA
Neuro-Oncology·2023Open Access
EPCO-14. IDENTIFYING EPIGENETIC VULNERABILITIES OF MINIMAL RESIDUAL DISEASE IN GLIOBLASTOMA USING IN VIVO CRISPR SCREENS
Neuro-Oncology·2023Open Access
CCRG-03. KAT5 REGULATES DEVELOPMENTAL TRANSITIONS AND CELLULAR HETEROGENEITY IN AN <i>IN VIVO</i> MODEL OF GLIOBLASTOMA
Neuro-Oncology·2023Open Access
Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations
Cell Reports·2023· 23 citedOpen Access
Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice
PLoS ONE·2023· 10 citedOpen Access
Abstract PR005: Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3’ untranslated region mutations
Cancer Research·2023
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Frequent Co-authors

Gregory J. Hannon(11), Chad M. Toledo(9), Philip Corrin(8), Sonali Arora(8), James M. Olson(7), Jacob Herman(7), Pia Hoellerbauer(6), Ryan Basom(6), Michele A. Cleary(5), Jun Zhu(5), Yu Ding(5), Jeongwu Lee(5), Steven M. Pollard(5), Jennifer G. DeLuca(5), Ravi Sachidanandam(4), Eunjee Lee(4), Emily J. Girard(4), Christopher Plaisier(4), Do‐Hyun Nam(4), Christopher G. Hubert(4)