Jay W. Heinecke

University of Washington — United States

Immunology and Microbiology · Life Sciences

109h-index37.3kcitations352works7.02yr avg
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Research Topics

Neutrophil, Myeloperoxidase and Oxidative Mechanisms(81), Diabetes, Cardiovascular Risks, and Lipoproteins(71), Nitric Oxide and Endothelin Effects(50), Cholesterol and Lipid Metabolism(49), Antioxidant Activity and Oxidative Stress(47)

Publications352 total

Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL
Journal of Lipid Research·2025· 2 citedOpen Access
Inclusion of ΑVβ3 integrin into extracellular vesicles in a caveolin-1 tyrosine-14- phosphorylation dependent manner and subsequent transfer to recipient melanoma cells promotes migration, invasion and metastasis
Cell Communication and Signaling·2025· 6 citedOpen Access
Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes
Journal of Lipid Research·2025Open Access
Extracellular vesicle inclusion of aVb3 integrin dependent on caveolin-1 tyrosine-14 phosphorylation and subsequent transfer to recipient melanoma cells promotes migration, invasion and metastasis
2024Open Access
APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1
Journal of Lipid Research·2024· 8 citedOpen Access
Distinct roles of size-defined HDL subpopulations in cardiovascular disease
Current Opinion in Lipidology·2024· 7 cited
Quantification of high-density lipoprotein particle number by proton nuclear magnetic resonance: don’t believe the numbers
Current Opinion in Lipidology·2024· 3 citedOpen Access
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference
Alzheimer s & Dementia·2024· 29 citedOpen Access
High‐Density Lipoprotein Particle Concentration and Size Predict Incident Coronary Artery Disease Events in a Cohort With Type 1 Diabetes
Journal of the American Heart Association·2024· 14 citedOpen Access
Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis
Circulation Research·2024· 12 citedOpen Access
A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling
Journal of Lipid Research·2024· 1 citedOpen Access
Sex differences in the associations of HDL particle concentration and cholesterol efflux capacity with incident coronary artery disease in type 1 diabetes: The RETRO HDLc cohort study
Journal of clinical lipidology·2024· 9 citedOpen Access
Does small HDL’s function improve when lipid-lowering alters its composition?
Journal of Lipid Research·2024Open Access
Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs
Circulation·2023· 30 citedOpen Access
HDL Particle Concentration and Size Predict Incident Coronary Artery Disease Events in People with Type 1 Diabetes
2023· 1 citedOpen Access
Flipped C-Terminal Ends of APOA1 Promote ABCA1-dependent Cholesterol Efflux by Small HDLs
2023· 4 citedOpen Access
Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health
Science Advances·2023· 23 citedOpen Access
Phospholipid transport by ABCA1: the extracellular translocase or alternating access model?
Current Opinion in Lipidology·2023· 5 citedOpen Access
Specialized Cellular Domains for ABCA1-mediated Cholesterol Efflux Detected by Quantitative Electron Microscopy
Microscopy and Microanalysis·2023Open Access
Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine model
Journal of Neuroinflammation·2023· 58 citedOpen Access
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Frequent Co-authors

Alan Chait(12), Subramaniam Pennathur(9), Jaeman Byun(6), John F. Oram(6), Stanley L. Hazen(6), H. R. Rosen(4), Xiaoyun Fu(4), Christiaan Leeuwenburgh(4), Fong‐Fu Hsu(4), Tomáš Vaisar(3), Pattie S. Green(3), Sean Y. Kassim(3), Pragya Singh(3), Randolph L. Geary(3), Robert S. Rosenson(3), Philip J. Barter(3), Anatol Kontush(3), Anuradha Vivekanandan‐Giri(3), Constanze Bergt(3), Jan R. Crowley(3)