Mandy M. T. van Leent

Icahn School of Medicine at Mount Sinai — United States

Immunology and Microbiology · Life Sciences

21h-index1.9kcitations40works13.62yr avg
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Research Topics

Immune cells in cancer(12), Immune responses and vaccinations(12), Atherosclerosis and Cardiovascular Diseases(7), Immunotherapy and Immune Responses(5), Cardiac Fibrosis and Remodeling(4)

Publications40 total

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart
Immunity·2026
Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment
Science Advances·2026· 2 citedOpen Access
HDL-associated phosphatidylserine blunts myeloid activation and protects from atherosclerosis
2025Open Access
Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?
Arteriosclerosis Thrombosis and Vascular Biology·2025
Cortico-Limbic and Sensorimotor Network Connectivity Link Brain Function to Atherosclerosis in Chronic Stress: Beyond Amygdala-PFC
2025Open Access
Targeting mTOR in myeloid cells prevents infection-associated inflammation
iScience·2025· 6 citedOpen Access
Myocardial infarction augments sleep to limit cardiac inflammation and damage
Nature·2024· 64 citedOpen Access
TGF-β: A Wrench in the Gears of Arteriovenous Fistula Maturation
Arteriosclerosis Thrombosis and Vascular Biology·2024Open Access
Adaptive multi-epitope targeting and avidity-enhanced nanobody platform for ultrapotent, durable antiviral therapy
Cell·2024· 30 citedOpen Access
Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling
Cell Reports·2024· 12 citedOpen Access
Polymersomes with splenic avidity target red pulp myeloid cells for cancer immunotherapy
Nature Nanotechnology·2024· 22 citedOpen Access
Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer
npj Imaging·2024· 9 citedOpen Access
Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure
European Heart Journal·2024· 18 citedOpen Access
Uncovering atherosclerotic cardiovascular disease by PET imaging
Nature Reviews Cardiology·2024· 27 citedOpen Access
Acid ceramidase regulates innate immune memory
Cell Reports·2023· 14 citedOpen Access
Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells
Nature Biomedical Engineering·2023· 71 citedOpen Access
Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models
JACC Basic to Translational Science·2023· 15 citedOpen Access
Multidimensional immunoimaging to characterize the inflammatory reaction after permanent and temporary coronary artery occlusion in mice
European Heart Journal·2022· 1 citedOpen Access
Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation
Scientific Reports·2022· 39 citedOpen Access
Regulating trained immunity with nanomedicine
Nature Reviews Materials·2022· 105 citedOpen Access
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Frequent Co-authors

Willem J. M. Mulder(33), Zahi A. Fayad(26), Carlos Pérez‐Medina(21), Abraham J. P. Teunissen(21), Yohana C. Toner(17), Raphaël Duivenvoorden(16), Claudia Calcagno(15), Jazz Munitz(15), Thomas Reiner(13), Mihai G. Netea(12), Matthias Nahrendorf(11), Leo A. B. Joosten(11), Filip K. Świrski(10), Geoffrey Prévot(10), Max L. Senders(10), Jordi Ochando(9), Georgios Soultanidis(9), Alexander Maier(9), Ewelina Kluza(8), Esther Lutgens(8)