Valérie Domenga

Inserm — France

Medicine · Health Sciences

16h-index5.0kcitations21works0.02yr avg
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Research Topics

Cerebrovascular and genetic disorders(19), Cell Adhesion Molecules Research(10), Metalloenzymes and iron-sulfur proteins(7), Moyamoya disease diagnosis and treatment(6), Neurological diseases and metabolism(4)

Publications21 total

Vacuolisation intramyélinique comme principale anomalie de la substance blanche dans un modèle murin préclinique de CADASIL
Morphologie·2017
Lésions de la substance blanche dans la maladie Cadasil : une altération de l’homéostasie ionique et hydrique ?
Revue Neurologique·2014
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
Journal of Clinical Investigation·2010· 360 citedOpen Access
Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain
Brain·2009· 114 citedOpen Access
J022 Effecteurs du récepteur Notch3 dans la cellule musculaire lisse des petites artères
Archives of cardiovascular diseases·2009
Notch3 Is a Major Regulator of Vascular Tone in Cerebral and Tail Resistance Arteries
Arteriosclerosis Thrombosis and Vascular Biology·2008· 106 citedOpen Access
The archetypal R90C CADASIL–NOTCH3 mutation retains NOTCH3 function in vivo
Human Molecular Genetics·2007· 106 cited
Transgenic mice modeling CADASIL arteriopathy have impaired cerebrovascular reactivity
Journal of Cerebral Blood Flow & Metabolism·2005
Impaired Cerebral Vasoreactivity in a Transgenic Mouse Model of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Arteriopathy
Stroke·2005· 139 citedOpen Access
Impaired Vascular Mechanotransduction in a Transgenic Mouse Model of CADASIL Arteriopathy
Stroke·2004· 95 citedOpen Access
<i>Notch3</i> is required for arterial identity and maturation of vascular smooth muscle cells
Genes & Development·2004· 523 citedOpen Access
Pathogenic Mutations Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Differently Affect Jagged1 Binding and Notch3 Activity via the RBP/JK Signaling Pathway
The American Journal of Human Genetics·2004· 158 citedOpen Access
Transgenic Mice Expressing Mutant Notch3 Develop Vascular Alterations Characteristic of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
American Journal Of Pathology·2003· 223 cited
Krit1/cerebral cavernous malformation 1 mRNA is preferentially expressed in neurons and epithelial cells in embryo and adult
Mechanisms of Development·2002· 53 cited
Vascular Smooth Muscle Cells Are the Primary Target of the Events Leading from Notch3 Mutations to CADASIL
Research and perspectives in Alzheimer's disease·2002
Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis
The Lancet·2001· 250 cited
Splice site mutation causing a seven amino acid <i>Notch3</i> in-frame deletion in CADASIL
Neurology·2000· 83 cited
The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients
Journal of Clinical Investigation·2000· 591 citedOpen Access
<i>Notch3</i> Mutations in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), a Mendelian Condition Causing Stroke and Vascular Dementia
Annals of the New York Academy of Sciences·1997· 164 cited
A Human Homolog of Bacterial Acetolactate Synthase Genes Maps within the CADASIL Critical Region
Genomics·1996· 23 cited
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Frequent Co-authors

Anne Joutel(21), Elisabeth Tournier‐Lasserve(16), Hugues Chabriat(6), Katayoun Vahedi(5), Jacqueline Maciazek(5), Pierre Lacombe(5), Anne Ducros(4), Sonia Alamowitch(3), Emmanuelle Maréchal(3), Corinne Cruaud(3), F. Andreux(3), Françoise Chapon(3), Marie Monet(3), B. Lemaire(3), Christophe Corpechot(2), Philippe Mouton(2), Michaelle Cécillion(2), Céline Vayssière(2), Emmanuel‐Alain Cabanis(2), Marie Madeleine Ruchoux(2)