Elaine W. Raines

University of Washington — United States

Medicine · Health Sciences

80h-index28.1kcitations168works0.02yr avg
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Research Topics

Cell Adhesion Molecules Research(48), Protease and Inhibitor Mechanisms(25), Atherosclerosis and Cardiovascular Diseases(24), Adipokines, Inflammation, and Metabolic Diseases(19), Angiogenesis and VEGF in Cancer(11)

Publications168 total

Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation
Molecular and Cellular Biology·2018· 32 citedOpen Access
Abstract 493: Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor-1 is Shed by a Disintegrin and Metalloprotease 17 and Contributes to Stimulating Macrophage Proliferation in Inflammation
Arteriosclerosis Thrombosis and Vascular Biology·2018
Soy and Heart Disease Prevention: Potential Mechanisms Unrelated to Cholesterol Reduction Biology of Atherosclerotic Plaque Formation: Possible Role of Growth Factors in Lesion Development and the Potential Impact of Soy1
2016
The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors (atherosclerosis/wound healing/growth factors/extracellular matrix)
2016
Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17
Journal of Neuroscience·2015· 26 citedOpen Access
Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition
Molecular and Cellular Biology·2015· 23 citedOpen Access
Can the DNA Damage Response Be Harnessed to Modulate Atherosclerotic Plaque Phenotype?
Circulation Research·2015· 7 cited
TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination
Journal of Neuroscience·2014· 43 citedOpen Access
Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis
Cell Reports·2014· 86 citedOpen Access
Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival
Proceedings of the National Academy of Sciences·2013· 311 citedOpen Access
A Lactobacillus rhamnosus GG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor
Journal of Biological Chemistry·2013· 161 citedOpen Access
Technical Advance: Novel ex vivo culture method for human monocytes uses shear flow to prevent total loss of transendothelial diapedesis function
Journal of Leukocyte Biology·2013· 7 citedOpen Access
Macrophage ADAM17 Deficiency Augments CD36-Dependent Apoptotic Cell Uptake and the Linked Anti-Inflammatory Phenotype
Circulation Research·2013· 83 citedOpen Access
Monocyte ADAM17 Promotes Diapedesis during Transendothelial Migration: Identification of Steps and Substrates Targeted by Metalloproteinases
The Journal of Immunology·2013· 30 citedOpen Access
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults
Mechanisms of Development·2013· 33 citedOpen Access
Osteopontin mediates macrophage chemotaxis via α<sub>4</sub> and α<sub>9</sub> integrins and survival via the α<sub>4</sub> integrin
Journal of Cellular Biochemistry·2012· 103 citedOpen Access
Smooth Muscle Cell Plasticity
Circulation Research·2012· 158 citedOpen Access
EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
Cancer Cell·2012· 516 cited
Metalloproteinase-mediated Shedding of Integrin β2 Promotes Macrophage Efflux from Inflammatory Sites
Journal of Biological Chemistry·2011· 51 citedOpen Access
History of Discovery
Arteriosclerosis Thrombosis and Vascular Biology·2011· 53 citedOpen Access
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Frequent Co-authors

Russell Ross(25), Karin Bornfeldt(6), Bodo Levkau(5), Daniel F. Bowen‐Pope(4), Kyle J. Garton(4), Peter J. Gough(4), Peter J. Dempsey(4), Hidenori Koyama(4), Cecilia M. Giachelli(4), Lee M. Graves(4), E G Krebs(4), R. Ross(3), David K. Madtes(3), Barbara Herren(3), Yutaka Nakashima(2), Andrew Plump(2), Jan L. Breslow(2), M A Reidy(2), Michael B. Sporn(2), Carl Blobel(2)