Kazuhiko Yanai

Tohoku University — Japan

Immunology and Microbiology · Life Sciences

66h-index15.6kcitations694works1.02yr avg
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Research Topics

Mast cells and histamine(195), Receptor Mechanisms and Signaling(122), Alzheimer's disease research and treatments(103), Medical Imaging Techniques and Applications(92), Olfactory and Sensory Function Studies(90)

Publications693 total

Whole-body biodistribution of [18F]SMBT-1: a novel PET tracer for monoamine oxidase B imaging in healthy humans
Annals of Nuclear Medicine·2026Open Access
Kinetic and quantitative analysis of [18F]SMBT-1 PET imaging for monoamine oxidase B
Annals of Nuclear Medicine·2025· 2 citedOpen Access
Visualization of Apolipoprotein E-Binding Amyloid Plaques in Postmortem Alzheimer’s Disease Brains Using a Novel Fluorescent Probe THK-5320
ACS Chemical Neuroscience·2025· 1 cited
Balanced discussion about bilastine as a truly non-sedating antihistamine
Current Medical Research and Opinion·2025Open Access
INHIBITION OF HISTAMINE METABOLIZING ENZYME IN THE BRAIN REDUCES CATAPLEXY IN NARCOLEPSY MODEL MICE
The International Journal of Neuropsychopharmacology·2025Open Access
Pharmacological inhibition of histamine <i>N</i>-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy
SLEEP·2024· 3 citedOpen Access
Amyloid accumulation in cases of suspected comorbid cerebral amyloid angiopathy and isolated cortical venous thrombosis
Journal of the Neurological Sciences·2024· 1 cited
＜Editors' Choice＞ Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function.
PubMed·2023Open Access
Radiosynthesis and evaluation of [18F]SNFT-1 for imaging early tau deposition
Nuclear Medicine and Biology·2023
Preclinical Characterization of the Tau PET Tracer [<sup>18</sup>F]SNFT-1: Comparison of Tau PET Tracers
Journal of Nuclear Medicine·2023· 18 citedOpen Access
Evaluation of 18F labeled glial fibrillary acidic protein binding nanobody and its brain shuttle peptide fusion proteins using a neuroinflammation rat model
PLoS ONE·2023· 2 citedOpen Access
Medical Studentsʼ Learning Through Academic Presentations Using Problem-Based Learning in Kampo Medicine
Kampo Medicine·2023Open Access
The large part German medicine has played in the development of experimental pharmacology in Japan
Naunyn-Schmiedeberg s Archives of Pharmacology·2022· 6 cited
Age-related increase of monoamine oxidase B in amyloid-negative cognitively unimpaired elderly subjects
Annals of Nuclear Medicine·2022· 2 cited
Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice
Neuropharmacology·2022· 8 cited
Oral histidine intake improves working memory through the activation of histaminergic nervous system in mice
Biochemical and Biophysical Research Communications·2022· 20 cited
Imaging of Reactive Astrogliosis by Positron Emission Tomography
Frontiers in Neuroscience·2022· 52 citedOpen Access
Assessing Reactive Astrogliosis with <sup>18</sup>F-SMBT-1 Across the Alzheimer Disease Spectrum
Journal of Nuclear Medicine·2022· 57 citedOpen Access
First-in-Humans Evaluation of <sup>18</sup>F-SMBT-1, a Novel <sup>18</sup>F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis
Journal of Nuclear Medicine·2022· 61 citedOpen Access
The Role of Chirality of [<sup>18</sup>F]SMBT-1 in Imaging of Monoamine Oxidase-B
ACS Chemical Neuroscience·2022· 11 cited
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Frequent Co-authors

Nobuyuki Okamura(24), Shozo Furumoto(18), Ryuichi Harada(15), Yukitsuka Kudo(15), Manabu Tashiro(12), Hiroyuki Arai(11), Ren Iwata(10), Masatoshi Itoh(9), Victor L. Villemagne(7), Takeo Yoshikawa(7), Michelle T. Fodero‐Tavoletti(6), Rachel S. Mulligan(6), Katsutoshi Furukawa(6), Aiko Ishiki(6), Tetsuro Tago(6), Takehiko Watanabe(6), Christopher C. Rowe(5), Colin L. Masters(5), Naoki Tomita(5), Kotaro Hiraoka(5)