Richard A. Zager

University of Washington — United States

Medicine · Health Sciences

40h-index6.3kcitations86works0.72yr avg
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Research Topics

Acute Kidney Injury Research(21), Heme Oxygenase-1 and Carbon Monoxide(14), Electrolyte and hormonal disorders(9), Chronic Kidney Disease and Diabetes(8), Erythrocyte Function and Pathophysiology(8)

Publications86 total

Veverimer, a Nonabsorbed Gastrointestinal Tract HCl Binder, Decreases Renal Ammoniagenesis and Mitigates Nephrotoxic Serum Nephritis
Kidney360·2025Open Access
RBT-1, A Pro-Oxidant Preconditioning Agent, Mitigates Syndecan-1 Shedding in Patients Undergoing Cardiac Surgery and Following Experimental AKI
Journal of Cardiothoracic Surgery and Therapeutics·2025Open Access
<scp>RBT</scp>‐1, a “preconditioning” agent, mitigates syndecan‐1 shedding in patients undergoing “on pump” cardiac surgery and following experimental <scp>AKI</scp>
Physiological Reports·2025· 2 citedOpen Access
Early loss of glutathione ‐s‐ transferase (GST) activity during diverse forms of acute renal tubular injury
Physiological Reports·2022· 10 citedOpen Access
Biomarker and Safety Results from a Phase 1b Study of RBT-9 in Healthy Volunteers and Subjects with CKD Stage 3/4
Journal of the American Society of Nephrology·2020· 1 cited
Design of PREVENT: A Phase 2 Study of the Effect of RBT-9 on Progression of COVID-19 Infection in High-Risk Individuals, Including Those with Advanced CKD
Journal of the American Society of Nephrology·2020
The NRF2 stimulating agent, tin protoporphyrin, activates protective cytokine pathways in healthy human subjects and in patients with chronic kidney disease
Physiological Reports·2020· 4 citedOpen Access
A Pharmacologic “Stress Test” for Assessing Select Antioxidant Defenses in Patients with CKD
Clinical Journal of the American Society of Nephrology·2020· 14 citedOpen Access
Episode 01 - Dr. Thomas Hallock
Digital Commons - University of South Florida (University of South Florida)·2020
Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway
American Journal of Physiology-Renal Physiology·2019· 21 citedOpen Access
Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury
Scientific Reports·2018· 35 citedOpen Access
Plasma and urinary p21: potential biomarkers of AKI and renal aging
American Journal of Physiology-Renal Physiology·2018· 30 citedOpen Access
The definition of acute kidney injury – Authors' reply
The Lancet·2018· 2 citedOpen Access
Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury
Translational research·2017· 17 cited
Acute kidney injury: a problem of definition
The Lancet·2017· 91 citedOpen Access
Alpha 1 Microglobulin: A Potentially Paradoxical Anti-Oxidant Agent
Advanced Techniques in Biology & Medicine·2017· 9 citedOpen Access
Combined iron sucrose and protoporphyrin treatment protects against ischemic and toxin-mediated acute renal failure
Kidney International·2016· 33 citedOpen Access
Renal Cortical Pyruvate as a Potentially Critical Mediator of Acute Kidney Injury
Nephron Clinical Practice·2014· 15 cited
Rapid Renal Alpha-1 Antitrypsin Gene Induction in Experimental and Clinical Acute Kidney Injury
PLoS ONE·2014· 32 citedOpen Access
Renal Cortical Pyruvate Depletion during AKI
Journal of the American Society of Nephrology·2014· 83 citedOpen Access
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Frequent Co-authors

Ali C.M. Johnson(18), Kristin M. Burkhart(6), Sherry Y. Hanson(6), Mineo Iwata(4), Steve Lund(3), Michael J. Ryan(2), Theodore A. Gooley(2), Evan D. Kharasch(2), C R Bredl(2), K Becker(2), James Herrington(2), Kirsten B. Frostad(2), Gretchen Johnson(1), J. M. W. KIRK(1), Sally M. Fuerstenberg(1), Beverly Torok‐Storb(1), Stacey Ruiz(1), Pablo E. Pérgola(1), Nosratola D. Vaziri(1), Julie R. Zivin(1)