Randolph Lopez

Alpha Technologies (Canada) — Canada

Medicine · Health Sciences

13h-index1.9kcitations33works1.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(15), Advanced biosensing and bioanalysis techniques(14), DNA and Biological Computing(12), Advanced Biosensing Techniques and Applications(7), Environmental DNA in Biodiversity Studies(6)

Publications33 total

AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity
mAbs·2025· 4 citedOpen Access
Abstract 7015: Intelligent molecular glue discovery by identifying glueable ligase-target pairs at scale
Cancer Research·2025
AlphaBind, a Domain-Specific Model to Predict and Optimize Antibody-Antigen Binding Affinity
2024· 2 citedOpen Access
1087 Preclinical development of cis-acting, affinity tuned immunocytokine for cancer immunotherapy
Regular and Young Investigator Award Abstracts·2024Open Access
Abstract 4500: A high-throughput approach to discover and characterize glueable ligase-target pairs
Cancer Research·2024
Abstract 2477: Selective IL-21 and IFN-alpha immunocytokines engineered using the AlphaSeq platform
Cancer Research·2024
High-throughput ML-guided design of diverse single-domain antibodies against SARS-CoV-2
2023· 8 citedOpen Access
1198 Cytokine affinity tuning and antibody discovery/optimization using the <i>AlphaSeq</i> and <i>AlphaBind</i> platforms to generate targeted immuno-oncology therapeutics
Regular and Young Investigator Award Abstracts·2023Open Access
Machine learning optimization of candidate antibody yields highly diverse sub-nanomolar affinity antibody libraries
Nature Communications·2023· 85 citedOpen Access
Abstract LB333: Cytokine affinity tuning using the <i>AlphaSeq</i> platform to generate targeted immuno-oncology therapeutics
Cancer Research·2023
Machine Learning Optimization of Candidate Antibodies Yields Highly Diverse Sub-nanomolar Affinity Antibody Libraries
Figshare·2023Open Access
A dataset comprised of binding interactions for 104,972 antibodies against a SARS-CoV-2 peptide
Scientific Data·2022· 37 citedOpen Access
Massively multiplexed affinity characterization of therapeutic antibodies against SARS-CoV-2 variants
Antibody Therapeutics·2022· 11 citedOpen Access
mit-ll/AlphaSeq_Antibody_Dataset: Initial release of AlphaSeq Antibody Dataset
2021· 3 citedOpen Access
mit-ll/AlphaSeq_Antibody_Dataset: Initial release of AlphaSeq Antibody Dataset
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
mit-ll/AlphaSeq_Antibody_Dataset: Initial release of AlphaSeq Antibody Dataset
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants
2021· 8 citedOpen Access
Author Correction: Probing the physical limits of reliable DNA data retrieval
Nature Communications·2020· 13 citedOpen Access
Probing the physical limits of reliable DNA data retrieval
Nature Communications·2020· 117 citedOpen Access
DNA assembly for nanopore data storage readout
Nature Communications·2019· 137 citedOpen Access
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Frequent Co-authors

Luís Ceze(13), Karin Strauß(13), Emily Engelhart(13), Georg Seelig(12), Douglas M. Carmean(9), Ryan Emerson(9), Charles Lin(9), David Younger(9), Siena Dumas Ang(7), Daniel Guion(7), Mary Kelley(7), Lee Organick(6), James Bornholt(6), Leslie Shing(6), Matthew Walsh(5), Yuan-Jyue Chen(4), Sergey Yekhanin(4), Konstantin Makarychev(4), Miklós Z. Rácz(4), Colleen Shikany(4)