Thomas Happe

Ruhr University Bochum — Germany

Energy · Physical Sciences

63h-index12.2kcitations196works2.32yr avg
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Research Topics

Metalloenzymes and iron-sulfur proteins(156), Electrocatalysts for Energy Conversion(105), Photosynthetic Processes and Mechanisms(60), Algal biology and biofuel production(39), Advanced battery technologies research(31)

Publications196 total

Tuning the H <sub>2</sub> Production Activity of ToHydA by Molecular Simulation-Informed Protein Engineering
2025Open Access
Reconsidering the Enzyme Kinetics of [FeFe]-Hydrogenases: Improved Turnover Rates and New Insights into pH and Potential Dependence with Eu(II)-Based Solution Assays
Analytical Chemistry·2025Open Access
A Zundel Ion in the Catalytic Proton Transfer Pathway of [FeFe]- Hydrogenase
2025
Inhibition of [ <scp>FeFe</scp> ]‐Hydrogenases by Small Molecules
2025
Hydrogen‐Producing Catalysts Based on Ferredoxin Scaffolds
Advanced Science·2025· 1 citedOpen Access
Protein Dynamics Affect O <sub>2</sub> -Stability of Group B [FeFe]-Hydrogenase from <i>Thermosediminibacter oceani</i>
Journal of the American Chemical Society·2025· 5 cited
Protein dynamics affect O <sub>2</sub> -stability of Group B [FeFe]-hydrogenase from <i>Thermosediminibacter oceani</i>
2025· 1 citedOpen Access
Distinct Valence States of the [4Fe4S] Cluster Revealed in the Hydrogenase <i>Cr</i> HydA1
Angewandte Chemie International Edition·2025· 3 citedOpen Access
Distinkte Valenzzustände des [4Fe4S]‐Clusters in der Hydrogenase <i>Cr</i>HydA1
Angewandte Chemie·2025Open Access
Structural determinants of oxygen resistance and Zn <sup>2+</sup> -mediated stability of the [FeFe]-hydrogenase from <i>Clostridium beijerinckii</i>
Proceedings of the National Academy of Sciences·2025· 9 citedOpen Access
Mesoporous Electrodes Enhance the Electrocatalytic Performance of [FeFe]‐Hydrogenase
Angewandte Chemie International Edition·2024· 5 citedOpen Access
Mesoporous Electrodes Enhance the Electrocatalytic Performance of [FeFe]‐Hydrogenase
Angewandte Chemie·2024Open Access
Distinct Valence States of the [4Fe4S] Cluster Revealed in the Hydrogenase CrHydA1
2024
Generation of molecular hydrogen (H<sub>2</sub>) by microalgae and their biocatalysts
at - Automatisierungstechnik·2024
A Conserved Binding Pocket in HydF is Essential for Biological Assembly and Coordination of the Diiron Site of [FeFe]-Hydrogenases
Journal of the American Chemical Society·2024· 5 cited
H2 production under stress: [FeFe]‑hydrogenases reveal strong stability in high pressure environments
Biophysical Chemistry·2024· 5 citedOpen Access
H2 Production Under Stress: [Fefe]-Hydrogenases Reveal Strong Stability in High Pressure Environments
SSRN Electronic Journal·2024Open Access
Oxygen sensitivity of [FeFe]-hydrogenase: a comparative study of active site mimics inside <i>vs.</i> outside the enzyme
Physical Chemistry Chemical Physics·2024· 7 citedOpen Access
The O<sub>2</sub>-stable [FeFe]-hydrogenase CbA5H reveals high resilience against organic solvents
Catalysis Science & Technology·2024· 2 citedOpen Access
The Alga Uronema belkae Has Two Structural Types of [FeFe]-Hydrogenases with Different Biochemical Properties
International Journal of Molecular Sciences·2023Open Access
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Frequent Co-authors

Martin Winkler(13), Wolfgang Lubitz(10), Anja Hemschemeier(9), Sven T. Stripp(7), Julian Esselborn(6), Edward J. Reijerse(6), Alexey Silakov(6), Anastasios Melis(5), Fräser A. Armstrong(5), Camilla Lambertz(4), Ulf‐Peter Apfel(4), Jifu Duan(4), Judith F. Siebel(3), Michael Haumann(3), Laurent Cournac(3), Gilles Peltier(3), Danuta Krawietz(3), Philipp Knörzer(3), Eckhard Hofmann(3), Moritz Senger(3)