Karthikeyani Chellappa

Brown University — United States

Medicine · Health Sciences

23h-index3.0kcitations42works4.32yr avg
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Research Topics

Sirtuins and Resveratrol in Medicine(16), Calcium signaling and nucleotide metabolism(8), Mitochondrial Function and Pathology(7), Diet and metabolism studies(5), Tryptophan and brain disorders(4)

Publications42 total

The microbiome at the centre of NAD+ supplementation
Nature Metabolism·2026
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
2024· 16 citedOpen Access
Immunofluorescence Protocol for HNF4α (P1 and P2 isoforms)
BIO-PROTOCOL·2024Open Access
Long-Term NMN Treatment Increases Lifespan and Healthspan in Mice in a Sex Dependent Manner
SSRN Electronic Journal·2024· 1 citedOpen Access
A subpopulation of lipogenic brown adipocytes drives thermogenic memory
Nature Metabolism·2023· 27 citedOpen Access
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury
Nature Metabolism·2023· 91 citedOpen Access
A microbiome-dependent gut–brain pathway regulates motivation for exercise
Nature·2022· 250 citedOpen Access
NAD precursors cycle between host tissues and the gut microbiome
Cell Metabolism·2022· 121 citedOpen Access
Reducing NAD(H) to amplify rhythms
Nature Metabolism·2021· 1 cited
The 2021 FASEB science research conference on NAD metabolism and signaling
Aging·2021· 1 citedOpen Access
NAD precursors cycle between host tissues and the gut microbiome
2021· 7 citedOpen Access
NAD+ flux is maintained in aged mice despite lower tissue concentrations
Cell Systems·2021· 106 citedOpen Access
SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside
JCI Insight·2021· 35 citedOpen Access
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
Nature Metabolism·2020· 307 citedOpen Access
NAD+ flux is maintained in aged mice
2020· 2 citedOpen Access
Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells
Aging·2020· 40 citedOpen Access
Nicotinamide riboside promotes liver regeneration by enhancing mitochondrial fatty acid oxidation
Journal of Hepatology·2020Open Access
4582 NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) DEPLETION MUST BE SEVERE TO INDUCE CARDIAC DYSFUNCTION AND EVENTUAL FAILURE
Journal of Clinical and Translational Science·2020Open Access
Mitochondrial NAD Transport
The FASEB Journal·2020
Age-related NAD+ decline
Experimental Gerontology·2020· 154 citedOpen Access
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Frequent Co-authors

Joseph A. Baur(29), Sarmistha Mukherjee(13), Joshua D. Rabinowitz(11), Melanie R. McReynolds(9), Frances M. Sladek(9), Marie E. Migaud(7), Qingwei Chu(7), James G. Davis(6), Hélène C. Descamps(6), Lauren M Paolella(6), Connor S.R. Jankowski(5), Christoph A. Thaiss(5), Wenyun Lu(5), Timothy S. Luongo(5), Philip Redpath(4), Antonio Dávila(4), Timothy Cox(4), Yashaswini R. Bhat(4), Rafaella T. Shima(4), Poonamjot Deol(4)